Patricia Ortiz-Tello

TL;DR: Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country, and two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function.

TL;DR: It is demonstrated that the ancestral components in admixed genomes can be traced back to distinct sub-continental source populations with far greater resolution than previously thought, even when limited pre-Columbian Caribbean haplotypes have survived.

TL;DR: A strong gradient in the Native American ancestry component of South American Latinos associated with country of origin and the geography of local indigenous populations is found, which can impact the understanding of population-level differences in biomedical traits and, thus, inform future medical genetic studies in the region.

TL;DR: In this paper, the first genome-wide association study on individuals from the Americas who are enriched for Native American heritage was performed, and the results demonstrate that studying admixed populations provides new insights in the delineation of the genetic architecture that underlies autoimmune and complex diseases.

TL;DR: In this article, the authors investigate the population genetic history of this region by characterizing patterns of genome-wide variation among previously diverged human populations and find that the Caribbean basin is home to some of the most complex interactions in recent history.