P
Patricia R. Robuck
Researcher at National Institutes of Health
Publications - 34
Citations - 6815
Patricia R. Robuck is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Placebo & Biliary atresia. The author has an hindex of 24, co-authored 34 publications receiving 5798 citations.
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Journal ArticleDOI
Pioglitazone, Vitamin E, or Placebo for Nonalcoholic Steatohepatitis
Arun J. Sanyal,Naga Chalasani,Kris V. Kowdley,Arthur J. McCullough,Anna Mae Diehl,Nathan M. Bass,Brent A. Neuschwander-Tetri,Joel E. Lavine,James Tonascia,Aynur Unalp,Mark L. Van Natta,Jeanne M. Clark,Elizabeth M. Brunt,David E. Kleiner,Jay H. Hoofnagle,Patricia R. Robuck +15 more
TL;DR: Vitamin E was superior to placebo for the treatment of nonalcoholic steatohepatitis in adults without diabetes, and significant benefits of pioglitazone were observed for some of the secondary outcomes.
Journal ArticleDOI
Effect of Vitamin E or Metformin for Treatment of Nonalcoholic Fatty Liver Disease in Children and Adolescents: The TONIC Randomized Controlled Trial
Joel E. Lavine,Jeffrey B. Schwimmer,Mark L. Van Natta,Jean P. Molleston,Jean P. Molleston,Karen F. Murray,Philip J. Rosenthal,Stephanie H. Abrams,Ann O. Scheimann,Arun J. Sanyal,Naga Chalasani,James Tonascia,Aynur Unalp,Jeanne M. Clark,Elizabeth M. Brunt,David E. Kleiner,Jay H. Hoofnagle,Patricia R. Robuck +17 more
TL;DR: Neither vitamin E nor metformin was superior to placebo in attaining the primary outcome of sustained reduction in ALT level in patients with pediatric NAFLD.
Journal ArticleDOI
Intravenous N-Acetylcysteine Improves Transplant-Free Survival in Early Stage Non-Acetaminophen Acute Liver Failure
William M. Lee,Linda S. Hynan,Lorenzo Rossaro,Robert J. Fontana,R. Todd Stravitz,Anne M. Larson,Timothy J. Davern,Natalie Murray,Timothy M. McCashland,Joan S. Reisch,Patricia R. Robuck +10 more
TL;DR: Intravenous NAC improves transplant-free survival in patients with early stage non-acetaminophen-related acute liver failure and typically require emergency liver transplantation.
Journal ArticleDOI
Portal chronic inflammation in nonalcoholic fatty liver disease (NAFLD): a histologic marker of advanced NAFLD-Clinicopathologic correlations from the nonalcoholic steatohepatitis clinical research network
Elizabeth M. Brunt,David E. Kleiner,Laura Wilson,Aynur Unalp,Cynthia E. Behling,Joel E. Lavine,Brent A. Neuschwander-Tetri,Stephanie H. Abrams,Diana Arceo,Denise Espinosa,Leanel Fairly,Diane Bringman,Carol Hawkins,Yao Chang Liu,Nicholette Rogers,Margaret Stager,Arthur J. McCullough,Srinivasan Dasarathy,Kevin Edwards,Ruth Sargent,Melissa J. Coffey,Karen F. Murray,Melissa Young,Parvathi Mohan,Kavita Nair,Manal F. Abdelmalek,Anna Mae Diehl,Marcia R. Gottfried,Cynthia D. Guy,Paul G. Killenberg,Samantha Kwan,Yi Ping Pan,Dawn Piercy,Melissa Smith,Prajakta Bhimalli,Naga Chalasani,Oscar W. Cummings,Lydia Lee,Linda Ragozzino,Raj Vuppalanchi,Barbara Calabrese,Debra Peglow,Ann O. Scheimann,Michael Torbenson,Ann Klipsch,Jean P. Molleston,Girish Subbarao,Sarah E. Barlow,Jose Derdoy,Joyce Hoffmann,Debra King,Joan Siegner,Susan Stewart,Brent A. Tetri,Judy Thompson,Cynthia Behling,Manual Celedon,Lisa Clark,Janis Durelle,Tarek Hassanein,Susana Mendoza,Jeffrey B. Schwimmer,Claude B. Sirlin,Tanya Stein,Allison Tobin,Kiran Bambha,Nathan M. Bass,Linda D. Ferrell,Danuta Filipowski,Raphael B. Merriman,Mark Pabst,Monique Rosenthal,Philip J. Rosenthal,Tessa Steel,Sherry Boyett,Daphne Bryan,Melissa J. Contos,Michael Fuchs,Martin F. Graham,Amy Jones,Velimir A. Luketic,Bimalijit Sandhu,Arun J. Sanyal,Carol Sargeant,Kimberly Selph,Melanie B. White,Kris V. Kowdley,Grace Gyurkey,Jody Mooney,James E. Nelson,Sarah Roberts,Cheryl Saunders,Alice Stead,Chia Wang,Matthew M. Yeh,Elizabeth M. Brunt,D Kleiner,Gilman D. Grave,Terry T.-K. Huang,Edward Doo,Jay E. Everhart,Jay H. Hoofnagle,Patricia R. Robuck,Leonard B. Seeff,Patricia Belt,Fred Brancati,Jeanne M. Clark,Ryan Colvin,Michel Donithan,Mika Green,Rosemary Hollick,Milana Isaacson,Wana Kim,Alison Lyndecker,Laura Miriel,Alice L. Sternberg,James Tonascia,Aynur Unalp-Arida,Mark L. Van Natta,Laura A. Wilson,Katherine P. Yates +120 more
TL;DR: Increased portal CI is associated with many clinical and pathologic features of progressive NAFLD in both adults and children, but not with ALT, autoantibodies, or lobular inflammation.
Journal ArticleDOI
Outcomes in adults with acute liver failure between 1998 and 2013: An observational cohort study
Adrian Reuben,Holly Tillman,Robert J. Fontana,Timothy Davern,Brendan M. McGuire,R. Todd Stravitz,Valerie Durkalski,Anne M. Larson,Iris Liou,Oren K. Fix,Michael L. Schilsky,Timothy M. McCashland,J. Eileen Hay,Natalie Murray,Obaid S. Shaikh,Daniel Ganger,Atif Zaman,Steven B. Han,Raymond T. Chung,Alastair D. Smith,Robert S. Brown,Jeffrey S. Crippin,M. Edwyn Harrison,David G. Koch,Santiago Munoz,K. Rajender Reddy,Lorenzo Rossaro,Raj Satyanarayana,Tarek Hassanein,A. James Hanje,Jody C. Olson,Ram Subramanian,Constantine J. Karvellas,Bilal Hameed,Averell H. Sherker,Patricia R. Robuck,William M. Lee +36 more
TL;DR: This large cohort study found that despite similar causes and severity of ALF among patients referred to specialty centers from 1998 to 2013, the proportion of patients listed for liver transplantation decreased and survival improved among those who did not receive a transplant as well asThose who did.