Author
Patrícia Sarlós
Other affiliations: University of Szeged
Bio: Patrícia Sarlós is an academic researcher from University of Pécs. The author has contributed to research in topics: Medicine & Inflammatory bowel disease. The author has an hindex of 18, co-authored 72 publications receiving 956 citations. Previous affiliations of Patrícia Sarlós include University of Szeged.
Papers
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TL;DR: Analysis of a large, nationwide, prospective cohort of AP cases allowed for the identification of important determinants of severity and mortality, and evidence-based guidelines should be observed rigorously to improve outcomes in AP.
Abstract: Objective
The aim of this study was to analyse the clinical characteristics of acute pancreatitis (AP) in a prospectively collected, large, multicentre cohort and to validate the major recommendations in the IAP/APA evidence-based guidelines for the management of AP
Design
Eighty-six different clinical parameters were collected using an electronic clinical research form designed by the Hungarian Pancreatic Study Group
Patients
600 adult patients diagnosed with AP were prospectively enrolled from 17 Hungarian centres over a two-year period from 1 January 2013
Main Results
With respect to aetiology, biliary and alcoholic pancreatitis represented the two most common forms of AP The prevalence of biliary AP was higher in women, whereas alcoholic AP was more common in men Hyperlipidaemia was a risk factor for severity, lack of serum enzyme elevation posed a risk for severe AP, and lack of abdominal pain at admission demonstrated a risk for mortality Abdominal tenderness developed in all the patients with severe AP, while lack of abdominal tenderness was a favourable sign for mortality Importantly, lung injury at admission was associated with mortality With regard to laboratory parameters, white blood cell count and CRP were the two most sensitive indicators for severe AP The most common local complication was peripancreatic fluid, whereas the most common distant organ failure in severe AP was lung injury Deviation from the recommendations in the IAP/APA evidence-based guidelines on fluid replacement, enteral nutrition and timing of interventions increased severity and mortality
Conclusions
Analysis of a large, nationwide, prospective cohort of AP cases allowed for the identification of important determinants of severity and mortality Evidence-based guidelines should be observed rigorously to improve outcomes in AP
167 citations
TL;DR: The identification of disease-associated interleukin and interleucin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis.
Abstract: Rheumatoid arthritis (RA) is an autoimmune disease, resulting in a chronic, systemic inflammatory disorder. It may affect many tissues and organs, but it primarily affects the flexible joints. In clinical practice patient care generates many questions about diagnosis, prognosis, and treatment. It is challenging for health care specialists to keep up to date with the medical literature. This review summarizes the pathogenesis, the polymorphisms of interleukin and interleukin genes and the standard available and possible future immunologic targets for RA treatment. The identification of disease-associated interleukin and interleukin receptor genes can provide precious insight into the genetic variations prior to disease onset in order to identify the pathways important for RA pathogenesis. The knowledge of the complex genetic background may prove useful for developing novel therapies and making personalized medicine based on the individual's genetics.
69 citations
TL;DR: The rates of local complications and organ failure and maximum CRP level were significantly and dose-dependently raised by hypertriglyceridemia, which dose-dependent aggravates the severity and related complications of AP.
66 citations
University of Pécs1, University of Szeged2, Hungarian Academy of Sciences3, Semmelweis University4, University of Debrecen5, Sichuan University6, Nanjing University7, Yangzhou University8, Slovak Medical University9, Hospital Universitari Arnau de Vilanova10, Autonomous University of Barcelona11, National Taiwan University12, University of Liverpool13, University of Pittsburgh14, Bogomolets National Medical University15, Iuliu Hațieganu University of Medicine and Pharmacy16, Ludwig Maximilian University of Munich17, University of Rijeka18, Vita-Salute San Raffaele University19, Medical University of Łódź20, Jagiellonian University Medical College21, University of Lisbon22, Catholic University of Korea23, New Generation University College24, The Catholic University of America25, Lund University26, Karolinska Institutet27, Manchester Royal Infirmary28, University of Kharkiv29
TL;DR: The authors formulated four consensus statements to urge reduction of unjustified antibiotic treatment in acute pancreatitis and to use procalcitonin rather than WBC or CRP as biomarkers to guide decision-making.
61 citations
TL;DR: The aim of the meta‐analysis was to quantify the risk of BE in the context of HPI and to estimate the prevalence of Barrett's esophagus and EAC at the same time.
Abstract: Introduction
The prevalence of Helicobacter pylori infection (HPI) has been decreasing in developed countries, with an increasing prevalence of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) at the same time. The aim of our meta‐analysis was to quantify the risk of BE in the context of HPI.
59 citations
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01 Jan 2011
2,529 citations
Journal Article•
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1,978 citations
Mayo Clinic1, National Institutes of Health2, Harvard University3, Science Applications International Corporation4, New York University5, Utrecht University6, University of Toronto7, University of Minnesota8, Mercy Medical Center (Baltimore, Maryland)9, University of California, San Francisco10, American Cancer Society11, Johns Hopkins University12, Fred Hutchinson Cancer Research Center13, University of Texas MD Anderson Cancer Center14, Yale University15, Vanderbilt University16, University of Paris-Sud17, German Cancer Research Center18, Veterans Health Administration19, Umeå University20, Georgetown University21, Memorial Sloan Kettering Cancer Center22, University of Pittsburgh23, Imperial College London24, French Institute of Health and Medical Research25, Academy of Athens26, Kaiser Permanente27, National Institute for Health and Welfare28, University at Buffalo29, Group Health Cooperative30
TL;DR: This study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies and identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.1 that are associated with multiple cancers.
Abstract: We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 prospective cohort studies and 8 case-control studies. Based on a logistic regression model for genotype trend effect that was adjusted for study, age, sex, self-described ancestry and five principal components, we identified eight SNPs that map to three loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Two correlated SNPs, rs9543325 (P = 3.27 x 10(-11), per-allele odds ratio (OR) 1.26, 95% CI 1.18-1.35) and rs9564966 (P = 5.86 x 10(-8), per-allele OR 1.21, 95% CI 1.13-1.30), map to a nongenic region on chromosome 13q22.1. Five SNPs on 1q32.1 map to NR5A2, and the strongest signal was at rs3790844 (P = 2.45 x 10(-10), per-allele OR 0.77, 95% CI 0.71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers. Our study has identified common susceptibility loci for pancreatic cancer that warrant follow-up studies.
494 citations
TL;DR: In this article, the authors provide the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for the evaluation of liver disease severity and prognosis.
428 citations