Patrick A. Curmi

TL;DR: Changes in the subunits of tubulin as it switches from its straight conformation to a curved one correlate with the loss of lateral contacts and provide a rationale for the rapid microtubule depolymerization characteristic of dynamic instability.

TL;DR: The X-ray structure of vinblastine bound to tubulin in a complex with the RB3 protein stathmin-like domain (RB3-SLD) explains vin Blastine-induced tubulin self-association into spiral aggregates at the expense of microtubule growth.

TL;DR: A new fabrication method to produce homogeneously fluorescent nanodiamonds with high yields is described, and the whole fabrication yield of colloidal quasi-spherical nanod diamonds was several orders of magnitude higher than those previously reported starting from microdiamonds.

TL;DR: Stable photoluminescence and high-contrast optically detected electron spin resonance (ODESR) from single nitrogen-vacancy (NV) defect centers created within ultrasmall, disperse nanodiamonds of radius less than 4 nm conclude that despite the tiny size of these nanod diamonds the photoactive nitrogen-Vacancy color centers retain their bulk properties to the benefit of numerous exciting potential applications in photonics, biomedical labeling, and imaging.

TL;DR: It is shown that nanodiamonds enter cells mainly by endocytosis, and converging data indicate that it is clathrin-mediated, and the results pave the way for the use of photoluminescent nanod diamonds in targeted intracellular labeling or biomolecule delivery.