Humanized monoclonal anti-human growth factor receptor 2 (HER2) antibody trastuzumab was approved for HER2 positive breast cancer patient treatment 11 years after the demonstration of HER2 gene amplification associated with the HER2 protein overexpression in breast cancer in 1987. HER2 positive status of breast cancer patients is assessed by HER2 gene amplification with in situ hybridization (ISH) and/or HER2 protein overexpression with immunohistochemistry (IHC). Because the discordance between quantitative HER2 ISH and subjective, semi-quantitative HER2 IHC assay results is a well-recognized issue of HER2 testing, we developed an assay combining HER2 ISH and HER2 IHC assays (HER2 gene-protein assay; HER2 GPA) as one test on the same tissue section. HER2 GPA allows pathologists to score the HER2 gene and HER2 protein status simultaneously at the individual cell level. The possibility that HER2 GPA may become the next generation of HER2 testing is discussed, particularly for cases in which it is difficult to assess the HER2 status of breast cancer patients due to the HER2 heterogeneity.

https://onlinelibrary.wiley.com/doi/pdf/10.1111/pin.12407

The assessment of HER2 status in breast cancer: the past, the present, and the future

Nostalgia is defined as the remembrance of prior experiences that are self-relevant, involve close others, and carry a predominantly positive affective tone (Wildschut et al. in J Pers Soc Psychol 91:975–993, 2006). Given nostalgia’s palliative function for coping with negative affect and self-threats (Sedikides et al. in Curr Dir Psychol Sci 17:304–307, 2008), the present research explores a psychological construct related to greater experience of nostalgia: regulatory mode. According to regulatory mode theory (Kruglanski et al. in J Pers Soc Psychol 79:793–815, 2000; Higgins et al. in Adv exp soc psychol 35:293–344, 2003), assessment is the aspect of self-regulation focused on evaluation, whereas locomotion is focused on goal progress. We hypothesized that emphasis of the assessment mode on evaluation would promote nostalgia, while emphasis of the locomotion mode on progress would prevent it. These predictions were corroborated in two studies that assessed regulatory modes as individual difference factors (Study 1) and induced them experimentally (Study 2). Implications of these findings for the self regulation process are considered.

Looking back or moving on: How regulatory modes affect nostalgia

After criticising the solutionist drift, this article argues for the need for three gestures, in order to build a more problematised Comparative Education: estrangement, that is, the ability to see the unknown and therefore to distance ourselves from what is already known; intercession, that is, the ability to perceive the importance of mediators; communication, that is, the ability to work in common with others, from different positions and perspectives. Based on these three gestures, the article argues for a Comparative Education that seeks to develop three lines of work: to build a science of difference, rather than a ‘solution’ that tends to homogenise educational directions throughout the world; to strengthen the public space, instead of contributing to the authority of experts; to revitalise the common, instead of yielding to the current fragmentation, in which we interact only with what is similar to us. The arguments are not limited to Southern Europe, as they intend to open up a set of ge...

Comparing Southern Europe: The Difference, the Public, and the Common.

Design research has recently turned to theoretical perspectives, including care ethics and posthumanism, to counter the industrial processes that have led to climate crisis. As design theorists and ethnographers of interaction, we researched experimental eco-farming in a community that shared many of these theoretical and ideological commitments. Our goal was not to offer an account of use and provide design implications in support of it. Instead, we chose to identify concrete practices and artifacts that embody the sorts of industrial transformations that we are seeking—even if they are manifest in an imperfect or partial form. We encountered practices focused on community building, local resilience to climate disruptions, experiments in eco-farming, economic survival, and attracting the next generation. One interlocutor translated these concerns into a simple binary, asking, “do we want to live here?” This paper contributes to a design research agenda that might (eventually) provide an affirmative answer.

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Patrick Cothias

Papers

La recherche du temps perdu