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Patrick Günther
Researcher at University of Bonn
Publications - 29
Citations - 2609
Patrick Günther is an academic researcher from University of Bonn. The author has contributed to research in topics: Immune system & Population. The author has an hindex of 12, co-authored 28 publications receiving 1890 citations. Previous affiliations of Patrick Günther include Ludwig Maximilian University of Munich & German Center for Neurodegenerative Diseases.
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Journal ArticleDOI
Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming
Anette Christ,Anette Christ,Patrick Günther,Mario A. Lauterbach,Peter Duewell,Debjani Biswas,Karin Pelka,Claus J. Scholz,Marije Oosting,Kristian Haendler,Kevin Baßler,Kathrin Klee,Jonas Schulte-Schrepping,Thomas Ulas,Simone J.C.F.M. Moorlag,Vinod Kumar,Min Hi Park,Min Hi Park,Leo A. B. Joosten,Laszlo Groh,Niels P. Riksen,Terje Espevik,Andreas Schlitzer,Yang Li,Michael L. Fitzgerald,Mihai G. Netea,Mihai G. Netea,Joachim L. Schultze,Joachim L. Schultze,Eicke Latz +29 more
TL;DR: NLRP3 mediates trained immunity following WD and could thereby mediate the potentially deleterious effects of trained immunity in inflammatory diseases.
Journal ArticleDOI
Specification of tissue-resident macrophages during organogenesis
Elvira Mass,Iván Ballesteros,Matthias Farlik,Florian Halbritter,Patrick Günther,Lucile Crozet,Lucile Crozet,Christian E. Jacome-Galarza,Kristian Händler,Johanna Klughammer,Yasuhiro Kobayashi,Elisa Gomez-Perdiguero,Joachim L. Schultze,Joachim L. Schultze,Marc Beyer,Marc Beyer,Christoph Bock,Christoph Bock,Christoph Bock,Frederic Geissmann,Frederic Geissmann,Frederic Geissmann +21 more
TL;DR: It is shown that EMP-derived precursors colonize embryonic tissues and simultaneously acquire a full core macrophage program, which indicates that differentiation of tissue-resident macrophages is an integral part of organogenesis and identifies a spatiotemporal molecular road map for the generation of macrophAGE diversity in vivo.
Journal ArticleDOI
Mapping the human DC lineage through the integration of high-dimensional techniques
Peter See,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Jinmiao Chen,Patrick Günther,Naomi McGovern,Sergio Erdal Irac,Merry Gunawan,Marc Beyer,Marc Beyer,Kristian Händler,Kaibo Duan,Hermi Sumatoh,Nicolas Ruffin,Mabel Jouve,Ester Gea-Mallorquí,Raoul C.M. Hennekam,Tony Kiat Hon Lim,Chan Chung Yip,Ming Wen,Benoit Malleret,Benoit Malleret,Ivy Low,Nurhidaya Binte Shadan,Charlene Foong Shu Fen,Alicia Tay,Josephine Lum,Francesca Zolezzi,Anis Larbi,Michael Poidinger,Jerry Kok Yen Chan,Qingfeng Chen,Laurent Rénia,Muzlifah Haniffa,Philippe Benaroch,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze,Evan W. Newell,Florent Ginhoux +40 more
TL;DR: Two unbiased high-dimensional technologies are employed to characterize the human DC lineage from bone marrow to blood and provide new markers that can be used to identify unambiguously pre-DC from pDC, including CD33, CX3CR1, CD2, CD5, and CD327.
Journal ArticleDOI
Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1
Erika Vacchelli,Yuting Ma,Elisa E. Baracco,Antonella Sistigu,David Enot,Federico Pietrocola,Heng Yang,Sandy Adjemian,Sandy Adjemian,Kariman Chaba,Michaela Semeraro,Michaela Semeraro,Michele Signore,Adele De Ninno,Valeria Lucarini,Francesca Peschiaroli,Luca Businaro,Annamaria Gerardino,Gwenola Manic,Thomas Ulas,Patrick Günther,Joachim L. Schultze,Oliver Kepp,Gautier Stoll,Celine Lefebvre,Celine Lefebvre,Claire Mulot,Claire Mulot,Francesca Castoldi,Sylvie Rusakiewicz,Sylvie Rusakiewicz,Sylvain Ladoire,Lionel Apetoh,José Manuel Bravo-San Pedro,Monica Lucattelli,Cécile Delarasse,Valérie Boige,Valérie Boige,Michel Ducreux,Michel Ducreux,Suzette Delaloge,Suzette Delaloge,Christophe Borg,Fabrice Andre,Giovanna Schiavoni,Ilio Vitale,Pierre Laurent-Puig,Pierre Laurent-Puig,Fabrizio Mattei,Laurence Zitvogel,Guido Kroemer +50 more
TL;DR: A loss-of-function allele of the gene coding for formyl peptide receptor 1 (FPR1) was identified that was associated with poor metastasis-free and overall survival in breast and colorectal cancer patients receiving adjuvant chemotherapy.
Journal ArticleDOI
Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2
Jil Sander,Susanne V. Schmidt,Branko Cirovic,Naomi McGovern,Naomi McGovern,Olympia Papantonopoulou,Anna-Lena Hardt,Anna C. Aschenbrenner,Christoph Kreer,Thomas Quast,Alexander M. Xu,Lisa Schmidleithner,Heidi Theis,Lan Do Thi Huong,Hermi Sumatoh,Mario A. Lauterbach,Jonas Schulte-Schrepping,Patrick Günther,Jia Xue,Kevin Baßler,Thomas Ulas,Kathrin Klee,Natalie Katzmarski,Stefanie Herresthal,Wolfgang Krebs,Bianca Martin,Eicke Latz,Eicke Latz,Eicke Latz,Kristian Händler,Michael Kraut,Waldemar Kolanus,Marc Beyer,Marc Beyer,Christine S. Falk,Bettina Wiegmann,Sven Burgdorf,Nicholas A. Melosh,Evan W. Newell,Florent Ginhoux,Andreas Schlitzer,Andreas Schlitzer,Joachim L. Schultze,Joachim L. Schultze +43 more
TL;DR: Monocyte‐derived dendritic cells are transcriptionally relate to in vivo inflammatory monocytes, that they integrate differentiation cues time dependently, and that in vitro differentiated monocytes are phenotypically heterogeneous.