P
Patrick J. Morrison
Researcher at Queen's University Belfast
Publications - 195
Citations - 9001
Patrick J. Morrison is an academic researcher from Queen's University Belfast. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 44, co-authored 187 publications receiving 8032 citations. Previous affiliations of Patrick J. Morrison include Belfast City Hospital & Belfast Health and Social Care Trust.
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Journal ArticleDOI
Cancer Risks for BRCA1 and BRCA2 Mutation Carriers: Results From Prospective Analysis of EMBRACE
Nasim Mavaddat,Susan Peock,Debra Frost,Steve Ellis,Radka Platte,Elena Fineberg,D. Gareth Evans,Louise Izatt,Rosalind A. Eeles,Julian Adlard,Rosemarie Davidson,Diana Eccles,Trevor Cole,Jackie Cook,Carole Brewer,Marc Tischkowitz,Fiona Douglas,Shirley Hodgson,Lisa Walker,Mary Porteous,Patrick J. Morrison,Lucy Side,M. John Kennedy,C. E. Houghton,Alan Donaldson,Mark T. Rogers,Huw Dorkins,Zosia Miedzybrodzka,Helen Gregory,Jacqueline Eason,Julian Barwell,Emma McCann,Alex Murray,Antonis C. Antoniou,Douglas F. Easton +34 more
TL;DR: Prospective risk estimates for breast cancer, ovarian cancer, and contralateral breast cancer in a prospective series of mutation carriers confirm findings from retrospective studies that common breast cancer susceptibility alleles in combination are predictive of breast cancer risk for BRCA2 carriers.
Journal ArticleDOI
Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register
Ji Morrow,Aline Russell,Eleanor Guthrie,L. Parsons,I. Robertson,R. Waddell,B. Irwin,R.C. McGivern,Patrick J. Morrison,John Craig +9 more
TL;DR: Only 4.2% of live births to women with epilepsy had an MCM, and polytherapy exposure was greater than for monotherapy exposure, and carbamazepine was associated with the lowest risk of MCM.
Journal ArticleDOI
Germline mutations in RAD51D confer susceptibility to ovarian cancer
Chey Loveday,Clare Turnbull,Emma Ramsay,Deborah Hughes,Elise Ruark,Jessica Frankum,Georgina Bowden,Bolot Kalmyrzaev,Margaret Warren-Perry,Katie Snape,Julian Adlard,Julian Barwell,Jonathan Berg,Angela F. Brady,Carole Brewer,G Brice,C Chapman,Jackie Cook,Rosemarie Davidson,Alan Donaldson,Fiona Douglas,Lynn Greenhalgh,Alex Henderson,Louise Izatt,Ajith Kumar,Fiona Lalloo,Zosia Miedzybrodzka,Patrick J. Morrison,Joan Paterson,Mary Porteous,Mark T. Rogers,Susan Shanley,Lisa Walker,Diana Eccles,D. Gareth Evans,Anthony Renwick,Sheila Seal,Christopher J. Lord,Alan Ashworth,Jorge S. Reis-Filho,Antonis C. Antoniou,Nazneen Rahman +41 more
TL;DR: It is shown that cells deficient in RAD51D are sensitive to treatment with a PARP inhibitor, suggesting a possible therapeutic approach for cancers arising in RAD 51D mutation carriers.
Journal ArticleDOI
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
Fergus J. Couch,Xianshu Wang,Lesley McGuffog,Andy C. H. Lee,Curtis Olswold,Karoline Kuchenbaecker,Penny Soucy,Zachary S. Fredericksen,Daniel Barrowdale,Joe Dennis,Mia M. Gaudet,Ed Dicks,Matthew L. Kosel,Sue Healey,Olga M. Sinilnikova,Adam M. Lee,Francois Bacot,Daniel Vincent,Frans B. L. Hogervorst,Susan Peock,Dominique Stoppa-Lyonnet,Anna Jakubowska,Paolo Radice,Rita K. Schmutzler,Susan M. Domchek,Marion Piedmonte,Christian F. Singer,Eitan Friedman,Mads Thomassen,Thomas Hansen,Susan L. Neuhausen,Csilla Szabo,Ignacio Blanco,Mark H. Greene,Beth Y. Karlan,Judy Garber,Catherine M. Phelan,Jeffrey N. Weitzel,Marco Montagna,Edith Olah,Irene L. Andrulis,Andrew K. Godwin,Drakoulis Yannoukakos,David E. Goldgar,Trinidad Caldés,Heli Nevanlinna,Ana Osorio,Mary Beth Terry,Mary B. Daly,Elizabeth J. van Rensburg,Ute Hamann,Susan J. Ramus,Amanda E. Toland,Maria A. Caligo,Olufunmilayo I. Olopade,Nadine Tung,Kathleen Claes,Mary S. Beattie,Melissa C. Southey,Evgeny N. Imyanitov,Marc Tischkowitz,Ramunas Janavicius,Esther M. John,Ava Kwong,Orland Diez,Judith Balmaña,Rosa B. Barkardottir,Banu Arun,Gad Rennert,Soo Hwang Teo,Patricia A. Ganz,Ian G. Campbell,Annemarie H. van der Hout,Carolien H.M. van Deurzen,Caroline Seynaeve,Encarna B. Gomez Garcia,Flora E. van Leeuwen,Hanne Meijers-Heijboer,Johannes J. P. Gille,Margreet G. E. M. Ausems,Marinus J. Blok,Marjolijn J. L. Ligtenberg,Matti A. Rookus,Peter Devilee,Senno Verhoef,Theo A. M. van Os,Juul T. Wijnen,Debra Frost,Steve Ellis,Elena Fineberg,Radka Platte,D. Gareth Evans,Louise Izatt,Rosalind A. Eeles,Julian Adlard,Diana Eccles,Jackie Cook,Carole Brewer,Fiona Douglas,Shirley Hodgson,Patrick J. Morrison,Lucy Side,Alan Donaldson,C. E. Houghton,Mark T. Rogers,Huw Dorkins,Jacqueline Eason,Helen Gregory,Emma McCann,Alex Murray,Alain Calender,Agnès Hardouin,Pascaline Berthet,Capucine Delnatte,Catherine Noguès,Christine Lasset,Claude Houdayer,Dominique Leroux,Etienne Rouleau,Fabienne Prieur,Francesca Damiola,Hagay Sobol,Isabelle Coupier,Laurence Venat-Bouvet,Laurent Castera,Marion Gauthier-Villars,Mélanie Léoné,Pascal Pujol,Sylvie Mazoyer,Yves-Jean Bignon,Elżbieta Złowocka-Perłowska,Jacek Gronwald,Jan Lubinski,Katarzyna Durda,Katarzyna Jaworska,Tomasz Huzarski,Amanda B. Spurdle,Alessandra Viel,Bernard Peissel,Bernardo Bonanni,Giulia Melloni,Laura Ottini,Laura Papi,Liliana Varesco,Maria Grazia Tibiletti,Paolo Peterlongo,Sara Volorio,Siranoush Manoukian,Valeria Pensotti,Norbert Arnold,Christoph Engel,Helmut Deissler,Dorothea Gadzicki,Andrea Gehrig,Karin Kast,Kerstin Rhiem,Alfons Meindl,Dieter Niederacher,Nina Ditsch,Hansjoerg Plendl,Sabine Preisler-Adams,Stefanie Engert,Christian Sutter,Raymonda Varon-Mateeva,Barbara Wappenschmidt,Bernhard H. F. Weber,Brita Arver,Marie Stenmark-Askmalm,Niklas Loman,Richard Rosenquist,Zakaria Einbeigi,Katherine L. Nathanson,Timothy R. Rebbeck,Stephanie V. Blank,David E. Cohn,Gustavo C. Rodriguez,Laurie Small,Michael Friedlander,Victoria L. Bae-Jump,Anneliese Fink-Retter,Christine Rappaport,Daphne Gschwantler-Kaulich,Georg Pfeiler,Muy-Kheng Tea,Noralane M. Lindor,Bella Kaufman,Shani Shimon Paluch,Yael Laitman,Anne-Bine Skytte,Anne-Marie Gerdes,Inge Søkilde Pedersen,Sanne Traasdahl Moeller,Torben A Kruse,Uffe Birk Jensen,Joseph Vijai,Kara Sarrel,Mark E. Robson,Noah D. Kauff,Anna Marie Mulligan,Gord Glendon,Hilmi Ozcelik,Bent Ejlertsen,Finn Cilius Nielsen,Lars Jønson,Mette K. Andersen,Yuan Chun Ding,Linda Steele,Lenka Foretova,Alex Teulé,Conxi Lázaro,Joan Brunet,Miquel Angel Pujana,Phuong L. Mai,Jennifer T. Loud,Christine Walsh,Jenny Lester,Sandra Orsulic,Steven A. Narod,Josef Herzog,Sharon Sand,Silvia Tognazzo,Simona Agata,Tibor Vaszko,JoEllen Weaver,Alexandra V. Stavropoulou,Saundra S. Buys,Atocha Romero,Miguel de la Hoya,Kristiina Aittomäki,Taru A. Muranen,Mercedes Durán,Wendy K. Chung,Adriana Lasa,Cecilia M. Dorfling,Alexander Miron,Javier Benitez,Leigha Senter,Dezheng Huo,Salina B. Chan,Anna P. Sokolenko,Jocelyne Chiquette,Laima Tihomirova,Tara M. Friebel,Bjarni A. Agnarsson,Karen H. Lu,Flavio Lejbkowicz,Paul A. James,Per Hall,Alison M. Dunning,Daniel C. Tessier,Julie M. Cunningham,Susan L. Slager,Chen Wang,Steven N. Hart,Kristen N. Stevens,Jacques Simard,Tomi Pastinen,Vernon S. Pankratz,Kenneth Offit,Douglas F. Easton,Georgia Chenevix-Trench,Antonis C. Antoniou +261 more
TL;DR: It is estimated that the breast cancer lifetime risks for the5% of BRCA1 carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk, and the ovarian cancer lifetime risk is 63% or higher, based on the known cancer risk-modifying loci.
Journal ArticleDOI
Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dube syndrome.
Laura S. Schmidt,Michael L. Nickerson,Michelle B. Warren,Gladys Glenn,Jorge R. Toro,Maria J. Merino,Maria L. Turner,Peter L. Choyke,Nirmala Sharma,James Peterson,Patrick J. Morrison,Eamonn R. Maher,McClellan M. Walther,Berton Zbar,W. Marston Linehan +14 more
TL;DR: Three families classified with familial renal oncocytoma were identified with BHD mutations, which represents the first disease gene associated with this rare form of renal neoplasm.