Author
Patrick K. Munywoki
Other affiliations: Pwani University College, Centers for Disease Control and Prevention, Kenya Medical Research Institute
Bio: Patrick K. Munywoki is an academic researcher from Wellcome Trust. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 24, co-authored 56 publications receiving 4775 citations. Previous affiliations of Patrick K. Munywoki include Pwani University College & Centers for Disease Control and Prevention.
Topics: Population, Medicine, Rhinovirus, Pneumonia, Seroprevalence
Papers
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Public Health Foundation of India1, University of Edinburgh2, University of Warwick3, Kenya Medical Research Institute4, University of Liverpool5, University of the Witwatersrand6, Alaska Native Tribal Health Consortium7, Johns Hopkins University8, International Military Sports Council9, University of Barcelona10, Dartmouth College11, Padjadjaran University12, University of Colorado Denver13, University of Split14
TL;DR: Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b, and the development of novel prevention and treatment strategies should be accelerated as a priority.
2,317 citations
University of Edinburgh1, University of Glasgow2, Johns Hopkins University3, University of Colorado Boulder4, University of the Witwatersrand5, International Military Sports Council6, Aga Khan University7, Medical Research Council8, King George's Medical University9, Kenya Medical Research Institute10, International Centre for Diarrhoeal Disease Research, Bangladesh11, Centers for Disease Control and Prevention12, University of Bergen13, Tribhuvan University14, University of Barcelona15, Utrecht University16, Emory University17, All India Institute of Medical Sciences18, University of Liverpool19, Boston Children's Hospital20, National Institute of Virology21, University of Zambia22, University of Health Sciences Antigua23, National Health Laboratory Service24, Chinese Center for Disease Control and Prevention25, Austral University26, University of Michigan27, Vanderbilt University28, University of New South Wales29, University of Otago30, University of Auckland31, Universidad del Valle de Guatemala32, University of Jordan33, University of Maryland, Baltimore34, National Scientific and Technical Research Council35, Research Institute for Tropical Medicine36, Pwani University College37, University of Cape Town38, University of Warwick39, Academy of Medical Sciences, United Kingdom40, Tohoku University41, École normale supérieure de Lyon42, John E. Fogarty International Center43, Charité44, Universidad Nacional de Asunción45, Tehran University of Medical Sciences46, Robert Koch Institute47, University of London48, University of New Mexico49, Capital Medical University50, Alaska Native Tribal Health Consortium51, Innlandet Hospital Trust52, Columbia University53, Mahidol University54, University of Pretoria55, Thailand Ministry of Public Health56, Peking Union Medical College57, Nagasaki University58, Public Health Foundation of India59
TL;DR: In this paper, the authors estimated the incidence and hospital admission rate of RSV-associated acute lower respiratory infection (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions.
1,470 citations
TL;DR: In a sample of Kenyan infants and children admitted with severe pneumonia to a rural hospital, RSV was the predominant viral pathogen and was associated with severe disease.
Abstract: Context Pneumonia is the leading cause of childhood death in sub-Saharan Africa. Comparative estimates of the contribution of causative pathogens to the burden of disease are essential for targeted vaccine development.
Objective To determine the viral etiology of severe pneumonia among infants and children at a rural Kenyan hospital using comprehensive and sensitive molecular diagnostic techniques.
Design, Setting, and Participants Prospective observational and case-control study during 2007 in a rural Kenyan district hospital. Participants were children aged 1 day to 12 years, residing in a systematically enumerated catchment area, and who either were admitted to Kilifi District Hospital meeting World Health Organization clinical criteria for severe pneumonia or very severe pneumonia; (2) presented with mild upper respiratory tract infection but were not admitted; or (3) were well infants and children attending for immunization.
Main Outcome Measures The presence of respiratory viruses and the odds ratio for admission with severe disease.
Results Of 922 eligible admitted patients, 759 were sampled (82% [median age, 9 months]). One or more respiratory viruses were detected in 425 of the 759 sampled (56% [95% confidence interval {CI}, 52%-60%]). Respiratory syncytial virus (RSV) was detected in 260 participants (34% [95% CI, 31%-38%]) and other respiratory viruses were detected in 219 participants (29%; 95% CI, 26%-32%), the most common being Human coronavirus 229E (n=51 [6.7%]), influenza type A (n=44 [5.8%]), Parainfluenza type 3 (n=29 [3.8%]), Human adenovirus (n=29 [3.8%]), and Human metapneumovirus (n=23 [3.0%]). Compared with well control participants, detection of RSV was associated with severe disease (5% in control participants; adjusted odds ratio, 6.11 [95% CI, 1.65-22.6]) while collectively, other respiratory viruses were not associated with severe disease (23% in control participants; adjusted odds ratio, 1.27 [95% CI, 0.64-2.52]).
Conclusion In a sample of Kenyan infants and children admitted with severe pneumonia to a rural hospital, RSV was the predominant viral pathogen. JAMA. 2010;303(20):2051-2057 www.jama.com
284 citations
University of Edinburgh1, Johns Hopkins University2, University of the Witwatersrand3, Institute of Tropical Medicine Antwerp4, Centers for Disease Control and Prevention5, Umeå University6, Yale University7, Aga Khan University8, University of Michigan9, University of Turku10, Universidad del Valle de Guatemala11, Ben-Gurion University of the Negev12, Clalit Health Services13, University of Jordan14, All India Institute of Medical Sciences15, Generalitat Valenciana16, Wellcome Trust17, National Institutes of Health18, Colorado School of Public Health19, Anschutz Medical Campus20, Thailand Ministry of Public Health21, Nagasaki University22, University of Cape Town23
TL;DR: The findings provide new and important evidence for maternal and paediatric influenza immunisation, and should inform future immunisation policy particularly in low-income and lower-middle-income countries.
203 citations
University Medical Center Utrecht1, Boston Children's Hospital2, University of Warwick3, Kenya Medical Research Institute4, Pwani University College5, University of the Witwatersrand6, Centers for Disease Control and Prevention7, Tohoku University8, Research Institute for Tropical Medicine9, University of Michigan10, Johns Hopkins University11, Ohio State University12, Nationwide Children's Hospital13, University of Jordan14, Vanderbilt University Medical Center15, University of Virginia16, McMaster University17, University of Colorado Boulder18, The Chinese University of Hong Kong19, Royal Children's Hospital20, University of Melbourne21, Aga Khan University22, University of Nottingham23, McGill University Health Centre24, University of Sheffield25, Utrecht University26, University of Edinburgh27
TL;DR: The results show that perinatal immunisation strategies for children aged younger than 6 months could have a substantial impact on RSV-related child mortality in low-income and middle-income countries.
180 citations
Cited by
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2010 aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex, using the Cause of Death Ensemble model.
11,809 citations
01 Jun 2012
TL;DR: SPAdes as mentioned in this paper is a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler and on popular assemblers Velvet and SoapDeNovo (for multicell data).
Abstract: The lion's share of bacteria in various environments cannot be cloned in the laboratory and thus cannot be sequenced using existing technologies. A major goal of single-cell genomics is to complement gene-centric metagenomic data with whole-genome assemblies of uncultivated organisms. Assembly of single-cell data is challenging because of highly non-uniform read coverage as well as elevated levels of sequencing errors and chimeric reads. We describe SPAdes, a new assembler for both single-cell and standard (multicell) assembly, and demonstrate that it improves on the recently released E+V-SC assembler (specialized for single-cell data) and on popular assemblers Velvet and SoapDeNovo (for multicell data). SPAdes generates single-cell assemblies, providing information about genomes of uncultivatable bacteria that vastly exceeds what may be obtained via traditional metagenomics studies. SPAdes is available online ( http://bioinf.spbau.ru/spades ). It is distributed as open source software.
10,124 citations
TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as discussed by the authors, the authors used the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data.
5,792 citations
Public Health Foundation of India1, University of Edinburgh2, Kenya Medical Research Institute3, University of Warwick4, University of Liverpool5, University of the Witwatersrand6, Alaska Native Tribal Health Consortium7, Johns Hopkins University8, University of Barcelona9, International Military Sports Council10, Dartmouth College11, Padjadjaran University12, University of Colorado Denver13, University of Split14
TL;DR: Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b, and the development of novel prevention and treatment strategies should be accelerated as a priority.
2,317 citations
1,669 citations