Patrik Brundin

TL;DR: The Dementia with Lewy Bodies (DLB) Consortium has refined its recommendations about the clinical and pathologic diagnosis of DLB, updating the previous report, which has been in widespread use for the last decade.

TL;DR: Two subjects with Parkinson's disease who had long-term survival of transplanted fetal mesencephalic dopaminergic neurons (11–16 years) developed α-synuclein–positive Lewy bodies in grafted neurons, providing the first evidence, to the authors' knowledge, that the disease can propagate from host to graft cells.

TL;DR: The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F]fluorodopa.

TL;DR: Recent findings indicate that the ubiquitin-proteasome system is involved in the pathogenesis of Parkinson's, Alzheimer's, Huntington's, and Prion diseases as well as amyotrophic lateral sclerosis, which raises hopes for a better understanding of the pathogenetic mechanisms involved in these diseases and for the development of novel, mechanism-based therapeutic modalities.

TL;DR: In vivo transfer of α-syn between host cells and grafted dopaminergic neurons in mice overexpressing human α- syn and results suggest that α- Syn propagation is a key element in the progression of Parkinson disease pathology.