Patrizia Panzanelli

TL;DR: It is shown that microglia actively engulf synaptic material and play a major role in synaptic pruning during postnatal development in mice and this work suggests that deficits in microglian function may contribute to synaptic abnormalities seen in some neurodevelopmental disorders.

TL;DR: GODZ-mediated palmitoylation represents a novel posttranslational modification that is selective forγ subunit-containing GABAA receptor subtypes, a mechanism that is likely to be important for regulated trafficking of these receptors in the secretory pathway.

TL;DR: Findings show that gephyrin is associated with a majority of GABAA‐receptor subtypes in brain, and document the usefulness of image deconvolution for analyzing the structural organization of the postsynaptic apparatus by fluorescence microscopy.

TL;DR: Evidence is discussed that GABAAR subtypes represent distinct receptor populations with a specific spatio‐temporal expression pattern in the developing and adult CNS, being endowed with unique functional and pharmacological properties, as well as being differentially regulated at the transcriptional, post‐transcriptional and translational levels.

TL;DR: A novel, profilin2‐dependent pathway, regulating synaptic physiology, neuronal excitability, and complex behavior is highlighted, with alterations in neurotransmitter release correlate with a hyperactivation of the striatum and enhanced novelty‐seeking behavior in profilIn2 mutant mice.