P
Paul A. Keller
Researcher at Illawarra Health & Medical Research Institute
Publications - 215
Citations - 5138
Paul A. Keller is an academic researcher from Illawarra Health & Medical Research Institute. The author has contributed to research in topics: Ring (chemistry) & Moiety. The author has an hindex of 30, co-authored 207 publications receiving 4241 citations. Previous affiliations of Paul A. Keller include University of Würzburg & University of Newcastle.
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Journal ArticleDOI
Atroposelective Synthesis of Axially Chiral Biaryl Compounds
Gerhard Bringmann,Anne J. Price Mortimer,Paul A. Keller,Mary J. Gresser,James Garner,Matthias Breuning +5 more
TL;DR: This Review classifies strategies in the asymmetric synthesis of axially chiral biaryl compounds according to their underlying concepts and critically evaluates their scope and limitations with reference to selected model reactions and applications.
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A twist of nature--the significance of atropisomers in biological systems.
TL;DR: The ability of natural receptors to possess differential binding between atropisomers is an important factor when considering active and inactive atrop isomeric drugs, and has required the development of new techniques for atropselective synthesis of desired targets.
Journal ArticleDOI
Atropselektive Synthese axial‐chiraler Biaryle
Gerhard Bringmann,Anne J. Price Mortimer,Paul A. Keller,Mary J. Gresser,James Garner,Matthias Breuning +5 more
TL;DR: In this paper, the Voraussetzungen fur das Auftreten von Axialchiralitat diskutiert werden anhand ausgewahlter Beispiele kritisch beurteilt.
Journal ArticleDOI
Control of hepatitis C: a medicinal chemistry perspective.
Journal ArticleDOI
Atroposelective Synthesis of Axially Chiral Biaryl Compounds
Gerhard Bringmann,Anne J. Price Mortimer,Paul A. Keller,Mary J. Gresser,James Garner,Matthias Breuning +5 more
TL;DR: A review of axially chirality in biaryl compounds can be found in this paper, where the asymmetric information is introduced into a preformed, but achiral-that is, symmetric or configurationally labile-biaryl compound.