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Paul B. Hopkins
Researcher at University of Washington
Publications - 101
Citations - 3976
Paul B. Hopkins is an academic researcher from University of Washington. The author has contributed to research in topics: DNA & Allylic rearrangement. The author has an hindex of 38, co-authored 101 publications receiving 3879 citations. Previous affiliations of Paul B. Hopkins include City University of New York & Colby College.
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Solution Structure of a Cisplatin-Induced DNA Interstrand Cross-Link
TL;DR: The NMR structure differs markedly from previously proposed models but accounts for the chemical reactivity, the unwinding, and the bending of cis-DDP interstrand cross-linked DNA and may be important in the formation and repair of these cross-links in chromatin.
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Metal ion enhanced helicity in synthetic peptides containing unnatural, metal-ligating residues
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Chlorosulfenylation-dehydrochlorination reactions. New and improved methodology for the synthesis of unsaturated aryl sulfides and aryl sulfones
Paul B. Hopkins,Philip L. Fuchs +1 more
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Covalent structure of a nitrogen mustard-induced DNA interstrand cross-link: an N7-to-N7 linkage of deoxyguanosine residues at the duplex sequence 5'-d(GNC)
Stacia M. Rink,Marjorie S. Solomon,Matthew J. Taylor,Sharanabasava B. Rajur,Larry W. McLaughlin,Paul B. Hopkins +5 more
TL;DR: Analysis of the mobility of cross-linked products by denaturing polyacrylamide gel electrophoresis (DPAGE) revealed the reaction to provide intrahelical, interstrand cross-links to be cleaved on exposure to aqueous piperidine at deoxyguanosine residues.
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Sequence preferences of DNA interstrand cross-linking agents: Importance of minimal DNA structural reorganization in the cross-linking reactions of mechlorethamine, cisplatin and mitomycin C
Paul B. Hopkins,Julie T. Millard,Jinsuk Woo,Margaret F. Weidner,James J. Kirchner,Snorri Th. Sigurdsson,Stanley Raucher +6 more
TL;DR: The structure of duplex DNA, the sequences which are cross-linked, and the atomic sites on DNA which are linked, indicate that cross-linking occurs preferentially at locations which will result in minimal distortion of B-DNA.