P
Paul B. Siegel
Researcher at Virginia Tech
Publications - 452
Citations - 13566
Paul B. Siegel is an academic researcher from Virginia Tech. The author has contributed to research in topics: Population & Antibody titer. The author has an hindex of 54, co-authored 445 publications receiving 12725 citations. Previous affiliations of Paul B. Siegel include Northern Illinois University & Rhône-Poulenc.
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Journal ArticleDOI
Whole-genome resequencing reveals loci under selection during chicken domestication
Carl-Johan Rubin,Michael C. Zody,Michael C. Zody,Jonas Eriksson,Jennifer R. S. Meadows,Ellen Sherwood,Matthew T. Webster,Liang Jiang,Max Ingman,Ted Sharpe,Sojeong Ka,Finn Hallböök,Francois Besnier,Örjan Carlborg,Bertrand Bed'Hom,Michèle Tixier-Boichard,Per Jensen,Paul B. Siegel,Kerstin Lindblad-Toh,Kerstin Lindblad-Toh,Leif Andersson,Leif Andersson +21 more
TL;DR: The authors used massively parallel sequencing to identify selective sweeps of favorable alleles and candidate mutations that have had a prominent role in the domestication of domestic chickens and their subsequent specialization into broiler (meat-producing) and layer (egg-consuming) chickens.
Journal ArticleDOI
Epistasis and the release of genetic variation during long-term selection.
TL;DR: It is shown that the genetic architecture of an apparently major locus for growth in chicken dissects into a genetic network of four interacting loci that mediate a considerably larger selection response than predicted by a single-locus model.
Journal ArticleDOI
Quantitative genetic background of the host influences gut microbiomes in chickens.
Lele Zhao,Wang Gang,Paul B. Siegel,Chuan He,Hezhong Wang,Wenjing Zhao,Zhengxiao Zhai,Fengwei Tian,Jianxin Zhao,Hao Zhang,Zikui Sun,Wei Chen,Yan Zhang,He Meng +13 more
TL;DR: Under a common diet and husbandry host quantitative genotype and gender influenced gut microbiota composite, two lines of chickens maintained under the same husbandry and dietary regimes differ by more than 10-fold in body weight at selection age.
Journal ArticleDOI
Production and Persistence of Antibodies in Chickens to Sheep Erythrocytes. 1. Directional Selection
Paul B. Siegel,W. B. Gross +1 more
TL;DR: Crosses of the selected populations indicated a heterotic effect for both selected traits and reciprocal effects for the persistence/nonpersistence of the antibody titers.
Journal ArticleDOI
Long-Term Divergent Selection for Eight-Week Body Weight in White Plymouth Rock Chickens
E. A. Dunnington,Paul B. Siegel +1 more
TL;DR: This paper provides an overview of results from a long-term (38 generations) selection experiment that developed lines from individual phenotypic selection for high or low body weight at 8 wk of age.