Paul Coote

TL;DR: A nonlinear complementary filter is proposed that combines accelerometer output for low frequency attitude estimation with integrated gyrometer output for high frequency estimation that is evaluated against the output from a full GPS/INS that was available for the data set.

TL;DR: VirtualFlow, an open-source drug discovery platform, enables the efficient preparation and virtual screening of ultra-large ligand libraries to identify molecules that bind with high affinity to target proteins.

TL;DR: A simple non-linear observer for attitude estimation based only on output from a typical inertial measurement unit (IMU) and dynamic pressure sensor embarked on a low-cost unmanned aerial vehicle and augmented with an integral state that ensures compensation of gyrometer bias is proposed.

TL;DR: An NMR-based fragment screen of full-length human BAX reveals a compound that sensitizes BAX activation by binding to a pocket formed by the junction of the α3/α4 and α5/α6 hairpins and informs fundamental mechanisms for conformational regulation of BAX.

TL;DR: In this paper, the authors used a combination of protein semisynthesis, biochemical analysis, NMR, X-ray crystallography and computational simulations on human PTEN and its sea squirt homolog, VSP, to obtain a detailed picture of how the phospho-C-tail forms a belt around the C2 and phosphatase domains of PTEN.