Paul Crea

TL;DR: It is concluded that >70% of breast cancers have an alteration in at least 1 component of the PI3K pathway and this might be exploited to therapeutic advantage especially in “basal‐like” cancers.

TL;DR: The association between basal phenotype and CAIX suggests that the more aggressive behaviour of these tumours is partly due to an enhanced hypoxic response and raises the possibility that targeted therapy against HIF pathway or downstream genes such as CAs may be an approach to investigate for these patients.

TL;DR: An immunohistochemical study measuring the levels and subcellular localization of β-catenin in 292 invasive ductal breast cancers with known treatment and outcome found a low β- catenin MTC score is associated with an adverse outcome in breast cancer, which may be of mechanistic significance in the disease process.

TL;DR: It is confirmed that c-Myc overexpression is a common event in breast cancer, and that this is associated with resistance to antiestrogens in vitro, and the development of an experimental paradigm for the discovery and validation of genes involved in estrogen signalling, and c- myc-mediated-antiestrogen resistance.

TL;DR: Zardawi S J, Zardawi I, McNeil C M, Millar E K A, McLeod D, Morey A L, Crea P, Murphy N C, Pinese M, Lopez‐Knowles E, Oakes S R, Ormandy C J, Qiu M R, Hamilton A, Spillane A, Soon Lee C, Sutherland R L, Musgrove E A & O’Toole S A .