P
Paul D. Coleman
Researcher at Arizona State University
Publications - 149
Citations - 11893
Paul D. Coleman is an academic researcher from Arizona State University. The author has contributed to research in topics: Hippocampus & Dentate gyrus. The author has an hindex of 48, co-authored 141 publications receiving 11060 citations. Previous affiliations of Paul D. Coleman include University of California, Riverside & University of Zurich.
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Journal ArticleDOI
Differences in the pattern of hippocampal neuronal loss in normal ageing and Alzheimer's disease
TL;DR: It is concluded that the neurodegenerative processes associated with normal ageing and with Alzheimer's disease are qualitatively different and that Alzheimer's Disease is not accelerated by ageing but is a distinct pathological process.
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Analysis of gene expression in single live neurons.
James Eberwine,Hermes H. Yeh,Kevin Miyashiro,Yanxiang Cao,Suresh Nair,Richard H. Finnell,Richard H. Finnell,Martha L. Zettel,Paul D. Coleman +8 more
TL;DR: Electrophysiological analysis coupled with molecular biology within the same cell will facilitate a better understanding of how changes at the molecular level are manifested in functional properties.
Journal ArticleDOI
Neuron numbers and dendritic extent in normal aging and Alzheimer's disease
Paul D. Coleman,Dorothy G. Flood +1 more
TL;DR: In this article, the authors reviewed evidence regarding neuron numbers and dendritic extent in normal aging rodent, monkey and human brain and in Alzheimer's disease and concluded that neuron loss and change in dendric extent are regionally specific, and corresponding brain regions do not always change in similar ways in rodents and primates.
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Gene expression changes in the course of normal brain aging are sexually dimorphic.
Nicole C. Berchtold,David H. Cribbs,Paul D. Coleman,Joseph M. Rogers,Elizabeth Head,Ronald C. Kim,Thomas G. Beach,Carol A. Miller,Juan C. Troncoso,John Q. Trojanowski,H. Ronald Zielke,Carl W. Cotman +11 more
TL;DR: Clear gender differences in brain aging were evident, suggesting that the brain undergoes sexually dimorphic changes in gene expression not only in development but also in later life, and that this balance is set differently in males and females.
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Dendritic growth in the aged human brain and failure of growth in senile dementia
Stephen J. Buell,Paul D. Coleman +1 more
TL;DR: A model of aging in the central nervous system in which one population of neurons dies and regresses and the other survives and grows is suggested, which appears to be the dominant population in aging without dementia.