P
Paul D.P. Pharoah
Researcher at University of Cambridge
Publications - 865
Citations - 82861
Paul D.P. Pharoah is an academic researcher from University of Cambridge. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 130, co-authored 794 publications receiving 71338 citations. Previous affiliations of Paul D.P. Pharoah include Fred Hutchinson Cancer Research Center & New Generation University College.
Papers
More filters
Journal ArticleDOI
Average risks of breast and ovarian cancer associated with BRCA1 or BRCA2 mutations detected in case series unselected for family history: a combined analysis of 22 studies
Antonis C. Antoniou,Paul D.P. Pharoah,Steven A. Narod,Harvey A. Risch,Jorunn E. Eyfjord,John L. Hopper,Niklas Loman,Håkan Olsson,Oskar T. Johannsson,Åke Borg,Barbara Pasini,Paolo Radice,Siranoush Manoukian,Diana Eccles,Nelson L.S. Tang,E. Olah,Hoda Anton-Culver,Ellen Warner,Jan Lubinski,Jacek Gronwald,Bohdan Górski,Hrafn Tulinius,Steinunn Thorlacius,Hannaleena Eerola,Heli Nevanlinna,Kirsi Syrjäkoski,Olli Kallioniemi,Deborah J. Thompson,Christopher H. Evans,Julian Peto,Julian Peto,Fiona Lalloo,D G R Evans,Douglas F. Easton +33 more
TL;DR: Risks in carriers were higher when based on index breast cancer cases diagnosed at <35 years of age and for variation in risk by mutation position for both genes, and some evidence for a reduction in risk in women from earlier birth cohorts is found.
Journal ArticleDOI
Genome-wide association study identifies novel breast cancer susceptibility loci
Douglas F. Easton,Karen A. Pooley,Alison M. Dunning,Paul D.P. Pharoah,Deborah J. Thompson,Dennis G. Ballinger,Jeffery P. Struewing,Jonathan J. Morrison,Helen I. Field,Robert Luben,Nicholas J. Wareham,Shahana Ahmed,Catherine S. Healey,Richard Bowman,Kerstin B. Meyer,Christopher A. Haiman,Laurence K. Kolonel,Brian E. Henderson,Loic Le Marchand,Paul Brennan,Suleeporn Sangrajrang,Valerie Gaborieau,Fabrice Odefrey,Chen-Yang Shen,Pei-Ei Wu,Hui-Chun Wang,Diana Eccles,D. Gareth Evans,Julian Peto,Olivia Fletcher,Nichola Johnson,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Georgia Chenevix-Trench,Georgia Chenevix-Trench,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Montserrat Garcia-Closas,Louise A. Brinton,Stephen J. Chanock,Jolanta Lissowska,Beata Peplonska,Heli Nevanlinna,Rainer Fagerholm,H Eerola,Daehee Kang,Keun-Young Yoo,Dong-Young Noh,Sei Hyun Ahn,David J. Hunter,Susan E. Hankinson,David G. Cox,Per Hall,Sara Wedrén,Jianjun Liu,Yen-Ling Low,Natalia Bogdanova,Peter Schu¨rmann,Do¨rk Do¨rk,Rob A. E. M. Tollenaar,Catharina E. Jacobi,Peter Devilee,Jan G. M. Klijn,Alice J. Sigurdson,Michele M. Doody,Bruce H. Alexander,Jinghui Zhang,Angela Cox,Ian W. Brock,Gordon MacPherson,Malcolm W.R. Reed,Fergus J. Couch,Ellen L. Goode,Janet E. Olson,Hanne Meijers-Heijboer,Hanne Meijers-Heijboer,Ans M.W. van den Ouweland,André G. Uitterlinden,Fernando Rivadeneira,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,John L. Hopper,Margaret R. E. McCredie,Margaret R. E. McCredie,Margaret R. E. McCredie,Melissa C. Southey,Melissa C. Southey,Graham G. Giles,Chris Schroen,Christina Justenhoven,Christina Justenhoven,Hiltrud Brauch,Hiltrud Brauch,Ute Hamann,Yon-Dschun Ko,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,_ kConFab,Arto Mannermaa,Veli-Matti Kosma,Vesa Kataja,Jaana M. Hartikainen,Nicholas E. Day,David Cox,Bruce A.J. Ponder +109 more
TL;DR: To identify further susceptibility alleles, a two-stage genome-wide association study in 4,398 breast cancer cases and 4,316 controls was conducted, followed by a third stage in which 30 single nucleotide polymorphisms were tested for confirmation.
Journal ArticleDOI
The clonal and mutational evolution spectrum of primary triple-negative breast cancers
Sohrab P. Shah,Andrew Roth,Rodrigo Goya,Arusha Oloumi,Gavin Ha,Yongjun Zhao,Gulisa Turashvili,Jiarui Ding,Kane Tse,Gholamreza Haffari,Ali Bashashati,Leah M Prentice,Jaswinder Khattra,Angela Burleigh,Damian Yap,Virginie Bernard,Andrew McPherson,Karey Shumansky,Anamaria Crisan,Ryan Giuliany,Alireza Heravi-Moussavi,Jamie Rosner,Daniel Lai,Inanc Birol,Richard Varhol,Angela Tam,Noreen Dhalla,Thomas Zeng,Kevin C. Ma,Simon K. Chan,Malachi Griffith,Annie Moradian,S.-W. Grace Cheng,Gregg B. Morin,Peter H. Watson,Karen A. Gelmon,Stephen Chia,Suet-Feung Chin,Christina Curtis,Christina Curtis,Oscar M. Rueda,Paul D.P. Pharoah,Sambasivarao Damaraju,John R. Mackey,Kelly Hoon,Timothy T. Harkins,Vasisht Tadigotla,Mahvash Sigaroudinia,Philippe Gascard,Thea D. Tlsty,Joseph F. Costello,Irmtraud M. Meyer,Connie J. Eaves,Wyeth W. Wasserman,Steven J.M. Jones,Steven J.M. Jones,David G. Huntsman,David G. Huntsman,Martin Hirst,Carlos Caldas,Marco A. Marra,Samuel Aparicio +61 more
TL;DR: It is shown that understanding the biology and therapeutic responses of patients with TNBC will require the determination of individual tumour clonal genotypes, and for the first time in an epithelial tumour subtype, the relative abundance of clonal frequencies among cases representative of the population is determined.
Journal ArticleDOI
The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes
Bernard Pereira,Suet-Feung Chin,Oscar M. Rueda,Hans Kristian Moen Vollan,Elena Provenzano,Helen Bardwell,Michelle Pugh,Linda Jones,Roslin Russell,Stephen John Sammut,Dana W.Y. Tsui,Bin Liu,Sarah-Jane Dawson,Sarah-Jane Dawson,Jean Abraham,Helen Northen,John F. Peden,Abhik Mukherjee,Gulisa Turashvili,Andrew R. Green,Steve McKinney,Arusha Oloumi,Sohrab P. Shah,Nitzan Rosenfeld,Leigh C. Murphy,David R. Bentley,Ian O. Ellis,Arnie Purushotham,Sarah E Pinder,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Helena M. Earl,Paul D.P. Pharoah,Mark T. Ross,Samuel Aparicio,Carlos Caldas +35 more
TL;DR: This study sequence 173 genes in 2,433 primary breast tumours that have copy number aberration, gene expression and long-term clinical follow-up data, and determines associations between mutations, driver CNA profiles, clinical-pathological parameters and survival.
Journal ArticleDOI
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk
Ganna Chornokur,Hui-Yi Lin,Jonathan Tyrer,Kate Lawrenson,Joe Dennis,Ernest K. Amankwah,Xiaotao Qu,Ya-Yu Tsai,Heather S.L. Jim,Zhihua Chen,Ann Y. Chen,Jennifer Permuth-Wey,Katja K.H. Aben,Hoda Anton-Culver,Natalia Antonenkova,Fiona Bruinsma,Elisa V. Bandera,Yukie Bean,Matthias W. Beckmann,Maria Bisogna,Line Bjørge,Natalia Bogdanova,Louise A. Brinton,Angela Brooks-Wilson,Clareann H. Bunker,Ralf Bützow,Ian G. Campbell,Karen Carty,Jenny Chang-Claude,Linda S. Cook,Daniel W. Cramer,Julie M. Cunningham,Cezary Cybulski,Agnieszka Dansonka-Mieszkowska,Andreas du Bois,Evelyn Despierre,Ed Dicks,Jennifer A. Doherty,Thilo Dörk,Matthias Dürst,Douglas F. Easton,Diana Eccles,Robert P. Edwards,Arif B. Ekici,Peter A. Fasching,Brooke L. Fridley,Yu-Tang Gao,Aleksandra Gentry-Maharaj,Graham G. Giles,Rosalind Glasspool,Marc T. Goodman,Jacek Gronwald,Patricia Harrington,Philipp Harter,Alexander Hein,Florian Heitz,Michelle A.T. Hildebrandt,Peter Hillemanns,Claus Høgdall,Estrid Høgdall,Satoyo Hosono,Anna Jakubowska,Allan Jensen,Bu-Tian Ji,Beth Y. Karlan,Linda E. Kelemen,Mellissa Kellar,Lambertus A. Kiemeney,Camilla Krakstad,Susanne K. Kjaer,Jolanta Kupryjanczyk,Diether Lambrechts,Sandrina Lambrechts,Nhu D. Le,Alice W. Lee,Shashi Lele,Arto Leminen,Jenny Lester,Douglas A. Levine,Dong Liang,Boon Kiong Lim,Jolanta Lissowska,Karen Lu,Jan Lubinski,Lene Lundvall,Leon F.A.G. Massuger,Keitaro Matsuo,Valerie McGuire,John R. McLaughlin,Iain A. McNeish,Usha Menon,Roger L. Milne,Francesmary Modugno,Kirsten B. Moysich,Roberta B. Ness,Heli Nevanlinna,Ursula Eilber,Kunle Odunsi,Sara H. Olson,Irene Orlow,Sandra Orsulic,Rachel Palmieri Weber,James Paul,Celeste Leigh Pearce,Tanja Pejovic,Liisa M. Pelttari,Malcolm C. Pike,Elizabeth M. Poole,Harvey A. Risch,Barry P. Rosen,Mary Anne Rossing,Joseph H. Rothstein,Anja Rudolph,Ingo B. Runnebaum,Iwona K. Rzepecka,Helga B. Salvesen,Eva S. Schernhammer,Ira Schwaab,Xiao-Ou Shu,Yurii B. Shvetsov,Nadeem Siddiqui,Weiva Sieh,Honglin Song,Melissa C. Southey,Beata Spiewankiewicz,Lara Sucheston,Soo-Hwang Teo,Kathryn L. Terry,Pamela J. Thompson,Lotte Ansgaard Thomsen,Ingvild L. Tangen,Shelley S. Tworoger,Anne M. van Altena,Robert A. Vierkant,Ignace Vergote,Christine Walsh,Shan Wang-Gohrke,Nicolas Wentzensen,Alice S. Whittemore,Kristine G. Wicklund,Lynne R. Wilkens,Anna H. Wu,Xifeng Wu,Yin Ling Woo,Hannah P. Yang,Wei Zheng,Argyrios Ziogas,Hanis Nazihah Hasmad,Andrew Berchuck,Edwin S. Iversen,Joellen M. Schildkraut,Susan J. Ramus,Ellen L. Goode,Alvaro N.A. Monteiro,Simon A. Gayther,Steven A. Narod,Paul D.P. Pharoah,Thomas A. Sellers,Catherine M. Phelan +158 more
TL;DR: Associations between inherited cellular transport gene variants and risk of EOC histologic subtypes are revealed on a large cohort of women.