Paul G. Richardson

TL;DR: The discovery of cis-regulatory domains that drive epidermal transcription suggests that C. intestinalis has arthropod-like Hox patterning in the epidermis, which is in addition to vertebrate-like CNS regulation.

TL;DR: In this article, the authors performed genome-scale CRISPR-Cas9-based gene editing studies and found that myeloma cell resistance to degraders of different targets (BET bromodomain proteins, CDK9) and operating through CRBN (degronimids) or VHL is primarily mediated by prevention of, rather than adaptation to, breakdown of the target oncoprotein; and this involves loss of function of the cognate E3 ligase or interactors/regulators of the respective cullin-RING ligase (C

TL;DR: Richardson et al. as discussed by the authors evaluated the efficacy and safety of POM+LoDex (POM 4 mg/d 1-21 d of each 28-d cycle; Dex 40 mg/wk) and POM alone in a randomized open-label study.

TL;DR: The current state of the field of proteasome inhibitors and their prototypic member, bortezomib, which was recently approved by the U.S. Food and Drug Administration for the treatment of advanced multiple myeloma, is reviewed.

TL;DR: KOS-953 has been successfully dose escalated with manageable toxicity and manageable toxicity in patients with relapsed and relapsed, refractory MM and extends the survival of mice after MM cells are injected and home to the marrow.