Paul G. Richardson

TL;DR: The first nonpathogenic B. xenovorans LB400 (LB400) isolate has been sequenced in this article, where the authors find significant differences in functional specialization between the three replicons of LB400.

TL;DR: Murine studies demonstrated a reduction in peripheral platelet count following a single bortezomib dose without negative effects on megakaryocytic cellularity, ploidy, or morphology, which suggest that bortzomib-induced thrombocytopenia is due to a reversible effect on megakinocyte function rather than a direct cytotoxic effect onmegakaryocytes or their progenitors.

TL;DR: SAHA sensitized MM.1S cells to death receptor-mediated apoptosis and inhibited the secretion of interleukin 6 induced in bone marrow stromal cells (BMSCs) by binding of MM cells, suggesting that it can overcome cell adhesion-mediated drug resistance.

TL;DR: Assessment of the presence, frequency, and functional characteristics of MDSCs in patients with newly diagnosed, relapsed, and relapsed/refractory multiple myeloma and the immunomodulatory effects of lenalidomide and bortezomib suggest that inhibition of the tumor-promoting and immune-suppressive functions of M DSCs in MM may represent a promising novel immune-based therapeutic strategy.

TL;DR: An update on recent advances in the management of patients with multiple myeloma who are not eligible for autologous stem-cell transplantation is provided to help clinicians ensure the most appropriate care for patients with Myeloma in everyday clinical practice.