Paul G. Richardson

TL;DR: Treatment with this sequence of high-dose melphalan followed by CTCb has not resulted in superior PFS to date, when compared with single-intensification CTCB.

TL;DR: The role of stem cell transplantation, plasma exchange, and kidney transplantation in the management of patients with paraprotein-related kidney disease continues to evolve.

TL;DR: The results demonstrate that MP-CTLs generated from SMM patients’ T cells show effective anti-MM responses including CD137 (4-1BB) upregulation, CTL proliferation, interferon-γ production and degranulation in an HLA-A2-restricted and peptide-specific manner and provide the rationale for clinical evaluation of a therapeutic vaccine to prevent or delay progression of SMM to active disease.

TL;DR: The results showed that only modest class-I HDAC inhibition is able to induce synergistic MM cytotoxicity in combination with Len, and these studies may provide the framework for utilizing HDACi in conjunction with Len to both avoid CRBN downregulation and enhance anti-MM activities.

TL;DR: Perifosine–lenalidomide–dexamethasone was well tolerated and demonstrated encouraging clinical activity in relapsed and relapsed/refractory MM.