P
Paul J. Kempen
Researcher at Technical University of Denmark
Publications - 59
Citations - 3100
Paul J. Kempen is an academic researcher from Technical University of Denmark. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 20, co-authored 49 publications receiving 2519 citations. Previous affiliations of Paul J. Kempen include Stanford University.
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Journal ArticleDOI
A brain tumor molecular imaging strategy using a new triple-modality MRI-photoacoustic-Raman nanoparticle
Moritz F. Kircher,Adam de la Zerda,Jesse V. Jokerst,Cristina Zavaleta,Paul J. Kempen,Erik Mittra,Kenneth L. Pitter,Ruimin Huang,Carl Campos,Frezghi Habte,Robert Sinclair,Cameron Brennan,Ingo K. Mellinghoff,Ingo K. Mellinghoff,Eric C. Holland,Sanjiv S. Gambhir +15 more
TL;DR: It is shown that a unique triple-modality magnetic resonance imaging–photoacoustic imaging–Raman imaging nanoparticle approach can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively.
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Photoacoustic Imaging of Mesenchymal Stem Cells in Living Mice via Silica-Coated Gold Nanorods
TL;DR: In this paper, the use of silica-coated gold nanorods as a contrast agent for photoacoustic imaging and quantitation of mesenchymal stem cells in rodent muscle tissue was reported.
Journal ArticleDOI
Shape matters: intravital microscopy reveals surprising geometrical dependence for nanoparticles in tumor models of extravasation.
Bryan Ronain Smith,Paul J. Kempen,Donna M. Bouley,Alexander M. Xu,Zhuang Liu,Nicholas A. Melosh,Hongjie Dai,Robert Sinclair,Sanjiv S. Gambhir +8 more
TL;DR: Real-time intravital microscopic imaging is used to meticulously examine how two different nanoparticles behave across three different murine tumor models to quantitatively indicate that nanoscale extravasational competence is highly dependent on nanoparticle geometry and is heterogeneous.
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Theranostic mesoporous silica nanoparticles biodegrade after pro-survival drug delivery and ultrasound/magnetic resonance imaging of stem cells.
Paul J. Kempen,Sarah L. Greasley,Kelly A. Parker,Jos L. Campbell,Huan-Yu Chang,Julian R. Jones,Robert Sinclair,Sanjiv S. Gambhir,Jesse V. Jokerst +8 more
TL;DR: Ranostic mesoporous silica nanoparticles that can increase cell survival through both diagnostic and therapeutic approaches are reported and the presence of IGF increased cell survival up to 40% versus unlabeled cells under in vitro serum-free culture conditions.
Journal ArticleDOI
Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma.
Kasper Bendix Johnsen,Kasper Bendix Johnsen,Annette Burkhart,Fredrik Melander,Paul J. Kempen,Jonas Bruun Vejlebo,Piotr Siupka,Morten Nielsen,Thomas Lars Andresen,Torben Moos +9 more
TL;DR: It is found that transferrin receptor-targeting increases the association between the immunoliposomes and primary endothelial cells in vitro, but that this does not correlate with increased cargo transcytosis.