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Paul J. Pistell
Researcher at Pennington Biomedical Research Center
Publications - 26
Citations - 6502
Paul J. Pistell is an academic researcher from Pennington Biomedical Research Center. The author has contributed to research in topics: Oxidative stress & Morris water navigation task. The author has an hindex of 19, co-authored 26 publications receiving 6032 citations. Previous affiliations of Paul J. Pistell include Towson University & National Institutes of Health.
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Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Cognitive impairment following high fat diet consumption is associated with brain inflammation.
Paul J. Pistell,Christopher D. Morrison,Sunita Gupta,Alecia G. Knight,Jeffrey N. Keller,Donald K. Ingram,Annadora J. Bruce-Keller +6 more
TL;DR: Data suggest that while different diet formulations can increase body weight, the ability of high fat diets to disrupt cognition is linked to brain inflammation.
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Canonical Nlrp3 Inflammasome Links Systemic Low-Grade Inflammation to Functional Decline in Aging
Yun-Hee Youm,Ryan W. Grant,Laura R. McCabe,Diana C. Albarado,Kim Y. Nguyen,Anthony Ravussin,Paul J. Pistell,Susan Newman,Renee T. Carter,Amanda Laque,Heike Münzberg,Clifford J. Rosen,Donald K. Ingram,J. Michael Salbaum,Vishwa Deep Dixit,Vishwa Deep Dixit +15 more
TL;DR: Nlrp3 inflammasome is revealed as an upstream target that controls age-related inflammation and an innovative therapeutic strategy to lower NLRp3 activity to delay multiple age- related chronic diseases is offered.
Journal ArticleDOI
High fat diet increases hippocampal oxidative stress and cognitive impairment in aged mice: implications for decreased Nrf2 signaling
Christopher D. Morrison,Paul J. Pistell,Donald K. Ingram,William D. Johnson,Ying Liu,Sun Ok Fernandez-Kim,Christy L. White,Megan N. Purpera,Romina María Uranga,Annadora J. Bruce-Keller,Jeffrey N. Keller +10 more
TL;DR: In this article, a 20-month old male C57Bl/6 mice were fed either "western diet" (41% fat), very high fat lard diet (60% fat) or corresponding control diets for 16 weeks and then assessed for changes in metabolism and brain homeostasis.
Journal ArticleDOI
Effects of high fat diet on Morris maze performance, oxidative stress, and inflammation in rats: contributions of maternal diet.
Christy L. White,Paul J. Pistell,Megan N. Purpera,Sunita Gupta,Sun-Ok Fernandez-Kim,Taylor L. Hise,Jeffrey N. Keller,Donald K. Ingram,Christopher D. Morrison,Annadora J. Bruce-Keller +9 more
TL;DR: It is suggested that HFD increases oxidative and inflammatory signaling in the brain, and further indicate that maternal HFD consumption might sensitize offspring to the detrimental effects of HFD.