Paul Lang

TL;DR: A common pathway by which diverse KIR can down-regulate NK and T cell activation programs is document and the sequence of the immunoreceptor tyrosine-based inhibitory motif (ITIM) is defined, initially described in FcgammaRIIB1, and expressed in both human and mouse KIR.

TL;DR: This review describes how cellular imaging technologies contribute to the drug discovery process and addresses both high-content and high-throughput needs.

TL;DR: Biochemical analysis revealed that at saturating ligand concentrations the ability of phage to stimulate some early signaling responses, such as Ca++ mobilization and tyrosine phosphorylation of syk or Igα, was highly affinity dependent, whereas the ability to stimulate Lyn phosphorylated was less so, suggesting that the BCR is capable of differential signaling.

TL;DR: It is found that VEGF potently stimulated a rapid and dose-dependent decrease in serine/threonine phosphorylation of p120 and p100, raising the possibility that the dephosphorylated of p 120 and p 100 triggered by VEGf may contribute to mechanisms regulating permeability and/or motility through modulation of cadherin adhesiveness.

TL;DR: A hit selection procedure based on machine learning methods is introduced and it is demonstrated that this method increases the hit verification rate significantly (up to a factor of 5), compared to conventional hit selection based on single readouts only.