P
Paul M. Hwang
Researcher at National Institutes of Health
Publications - 83
Citations - 19825
Paul M. Hwang is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Mitochondrion & Cancer. The author has an hindex of 42, co-authored 80 publications receiving 19023 citations. Previous affiliations of Paul M. Hwang include Johns Hopkins University School of Medicine & Howard Hughes Medical Institute.
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Journal ArticleDOI
Localization of nitric oxide synthase indicating a neural role for nitric oxide
TL;DR: It is demonstrated that NO synthase in the brain to be exclusively associated with discrete neuronal populations, and prominent neural localizations provided the first conclusive evidence for a strong association of NO with neurons.
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Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase.
David S. Bredt,Paul M. Hwang,Charles E. Glatt,Charles J. Lowenstein,Randall R. Reed,Randall R. Reed,Solomon H. Snyder +6 more
TL;DR: Cloning of a complementary DNA for brain nitric oxide synthase reveals recognition sites for NADPH, FAD, flavin mononucleotide and calmodulin as well as phosphorylation sites, indicating that the synthase is regulated by many different factors.
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Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.
TL;DR: The identity of neuronal NO synthase and NADPH diaphorase suggests a role for NO in modulating neurotoxicity, and is in line with previous work on neuronal messenger molecules.
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p53 Regulates Mitochondrial Respiration
Satoaki Matoba,Ju Gyeong Kang,Ju Gyeong Kang,Willmar D. Patino,Willmar D. Patino,Andrew Wragg,Andrew Wragg,Manfred Boehm,Manfred Boehm,Oksana Gavrilova,Oksana Gavrilova,Paula J. Hurley,Paula J. Hurley,Fred Bunz,Fred Bunz,Paul M. Hwang,Paul M. Hwang +16 more
TL;DR: It is shown that p53, one of the most frequently mutated genes in cancers, modulates the balance between the utilization of respiratory and glycolytic pathways, and Synthesis of Cytochrome c Oxidase 2 (SCO2) is identified as the downstream mediator of this effect.
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Nitric oxide synthase protein and mRNA are discretely localized in neuronal populations of the mammalian CNS together with NADPH diaphorase
TL;DR: Brain nitric oxide synthase has been purified and molecularly cloned from brain and its localization is absolutely coincident with NADPH diaphorase staining in both rat and primate brain.