Paul M. Lantos

Bio: Paul M. Lantos is an academic researcher from Duke University. The author has contributed to research in topics: Lyme disease & Borrelia burgdorferi. The author has an hindex of 20, co-authored 60 publications receiving 1179 citations. Previous affiliations of Paul M. Lantos include Boston Children's Hospital & Durham University.

Final Report of the Lyme Disease Review Panel of the Infectious Diseases Society of America

Abstract: In April 2008, the Infectious Diseases Society of America (IDSA) entered into an agreement with Connecticut Attorney General Richard Blumenthal to voluntarily undertake a special review of its 2006 Lyme disease guidelines. This agreement ended the Attorney General's investigation into the process by which the guidelines were developed. The IDSA agreed to convene an independent panel to conduct a one-time review of the guidelines. The Review Panel members, vetted by an ombudsman for potential conflicts of interest, reviewed the entirety of the 2006 guidelines, with particular attention to the recommendations devoted to post-Lyme disease syndromes. After multiple meetings, a public hearing, and extensive review of research and other information, the Review Panel concluded that the recommendations contained in the 2006 guidelines were medically and scientifically justified on the basis of all of the available evidence and that no changes to the guidelines were necessary.

Bartonella vinsonii subsp. berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease.

Abstract: Background Bartonella vinsonii subsp. berkhoffii is an important, emerging, intravascular bacterial pathogen that has been recently isolated from immunocompetent patients with endocarditis, arthritis, neurological disease and vasoproliferative neoplasia. Vector transmission is suspected among dogs and wild canines, which are the primary reservoir hosts. This investigation was initiated to determine if pets and family members were infected with one or more Bartonella species.

Chronic Lyme disease: the controversies and the science.

Abstract: The diagnosis of chronic Lyme disease has been embroiled in controversy for many years. This is exacerbated by the lack of a clinical or microbiologic definition, and the commonality of chronic symptoms in the general population. An accumulating body of evidence suggests that Lyme disease is the appropriate diagnosis for only a minority of patients in whom it is suspected. In prospective studies of Lyme disease, very few patients go on to have a chronic syndrome dominated by subjective complaints. There is no systematic evidence that Borrelia burgdorferi, the etiology of Lyme disease, can be identified in patients with chronic symptoms following treated Lyme disease. Multiple prospective trials have revealed that prolonged courses of antibiotics neither prevent nor alleviate such post-Lyme syndromes. Extended courses of intravenous antibiotics have resulted in severe adverse events, which in light of their lack of efficacy, make them contraindicated.

Update on Tick-Borne Rickettsioses around the World: a Geographic Approach

Abstract: Tick-borne rickettsioses are caused by obligate intracellular bacteria belonging to the spotted fever group of the genus Rickettsia. These zoonoses are among the oldest known vector-borne diseases. However, in the past 25 years, the scope and importance of the recognized tick-associated rickettsial pathogens have increased dramatically, making this complex of diseases an ideal paradigm for the understanding of emerging and reemerging infections. Several species of tick-borne rickettsiae that were considered nonpathogenic for decades are now associated with human infections, and novel Rickettsia species of undetermined pathogenicity continue to be detected in or isolated from ticks around the world. This remarkable expansion of information has been driven largely by the use of molecular techniques that have facilitated the identification of novel and previously recognized rickettsiae in ticks. New approaches, such as swabbing of eschars to obtain material to be tested by PCR, have emerged in recent years and have played a role in describing emerging tick-borne rickettsioses. Here, we present the current knowledge on tick-borne rickettsiae and rickettsioses using a geographic approach toward the epidemiology of these diseases.

Making Neighborhood-Disadvantage Metrics Accessible - The Neighborhood Atlas.

Abstract: Making Neighborhood-Disadvantage Metrics Accessible Better understanding of variations in neighborhood disadvantage could lead to improved insight into the sociobiologic mechanisms that underlie health disparities, which could, in turn, facilitate the development of improved therapeutics and interventions.

A practical guide to the American Community Survey (3-year estimates)

Abstract: Historically, most demographic data for states and substate areas were collected from the long version of the decennial census questionnaire. A “snapshot” of the characteristics of the population on the April 1 census date was available once every 10 years. The long form of the decennial census has been replaced by the American Community Survey (ACS) that has been conducted on an ongoing basis for the entire country since 2005. Instead of a snapshot in which all of the data are gathered at one time, the ACS aggregates data collected over time, making the results more difficult to interpret. However, the ACS data are updated annually.