Paul Macklin

TL;DR: In this paper, the authors provide an overview of multiscale modelling focusing on the growth phase of tumours and bypassing the initial stage of tumourigenesis, and limit the scope further by considering models of tumor progression that do not distinguish tumour cells by their age and do not consider immune system interactions nor do they describe models of therapy.

TL;DR: In this review, the most recent and important multiscale cancer modeling works that have successfully established a mechanistic link between different biological scales are introduced and biophysical, biochemical, and biomechanical factors are considered in these models.

TL;DR: A new multiscale mathematical model for solid tumour growth is presented which couples an improved model of tumour invasion with a model of malignant tumour-induced angiogenesis and demonstrates the importance of the coupling between the development and remodeling of the vascular network, the blood flow through the network and the tumour progression.

TL;DR: PhysiCell is demonstrated by simulating the impact of necrotic core biomechanics, 3-D geometry, and stochasticity on the dynamics of hanging drop tumor spheroids and ductal carcinoma in situ (DCIS) of the breast.

TL;DR: The NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution by supporting technology development, data acquisition, and detailed spatial mapping.