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Paul Talalay
Researcher at Johns Hopkins University
Publications - 77
Citations - 13324
Paul Talalay is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Sulforaphane & Broccoli sprouts. The author has an hindex of 45, co-authored 77 publications receiving 12459 citations. Previous affiliations of Paul Talalay include Johns Hopkins University School of Medicine.
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Journal ArticleDOI
The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
TL;DR: This review addresses the complex array of glucosinolates, the precursors of isothiocyanates, present in sixteen families of dicotyledonous angiosperms including a large number of edible species including Brassica vegetables.
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Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
Albena T. Dinkova-Kostova,W. David Holtzclaw,Robert N. Cole,Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Masayuki Yamamoto,Paul Talalay +7 more
TL;DR: This finding suggests that reaction of cysteine thiols is followed by rapid formation of protein disulfide linkages, which are the direct sensors of inducers of the phase 2 system.
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Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice.
Minerva Ramos-Gomez,Mi Kyoung Kwak,Patrick M. Dolan,Ken Itoh,Masayuki Yamamoto,Paul Talalay,Thomas W. Kensler +6 more
TL;DR: Oltipraz significantly reduced multiplicity of gastric neoplasia in wild-type mice by 55%, but had no effect on tumor burden in nrf2-deficient mice, highlighting the prime importance of elevated phase 2 gene expression in chemoprotection by this and similar enzyme inducers.
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Phytochemicals from Cruciferous Plants Protect against Cancer by Modulating Carcinogen Metabolism
Paul Talalay,Jed W. Fahey +1 more
TL;DR: Substantial evidence supports the view that phase 2 enzyme induction is a highly effective strategy for reducing susceptibility to carcinogens and an increasing number of phase 2 proteins that exert a variety of protective mechanisms are being identified.
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Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress
Albena T. Dinkova-Kostova,Karen T. Liby,Katherine K. Stephenson,W. David Holtzclaw,Xiangqun Gao,Nanjoo Suh,Charlotte R. Williams,Renee Risingsong,Tadashi Honda,Gordon W. Gribble,Michael B. Sporn,Paul Talalay +11 more
TL;DR: This work shows that synthetic triterpenoid analogues of oleanolic acid are extremely potent inducers of the phase 2 response [e.g., elevation of NAD(P)H-quinone oxidoreductase and heme oxygenase 1], which is a major protector of cells against oxidative and electrophile stress.