Paul Warrener

TL;DR: It is proposed that the size and complexity of the P. aeruginosa genome reflect an evolutionary adaptation permitting it to thrive in diverse environments and resist the effects of a variety of antimicrobial substances.

TL;DR: It is concluded that nitroimidazopyrans offer the practical qualities of a small molecule with the potential for the treatment of tuberculosis and bactericidal activity against both replicating and static M. tuberculosis.

TL;DR: Estimation of template dilution studies in the presence of human carrier DNA demonstrated that six human herpesviruses could be detected at levels at or below 100 genome equivalents per 100 ng of carrier DNA, suggesting that consensus primer PCR targeted to herpesviral DNA polymerase may prove to be useful in the detection and identification of known herpesvirus in clinical samples and the initial characterization of new herpesViral genomes.

TL;DR: Although it is unlikely that hyperexpression of AmrAB is the sole mechanism conferring the impermeability phenotype, it is believed that the Amr efflux system can contribute to a complex interaction of molecular events resulting in the aminoglycoside impermeable-type resistance phenotype.

TL;DR: Complementation of the cueA mutation restored in vitro tolerance to copper and virulence in a systemic model of infection to near wild-type levels and suggests the P. aeruginosa CueA protein may be important in maintaining copper homeostasis both in vitro and in vivo.