Paul Williams

TL;DR: The ability of CV026 to respond to a series of synthetic AHL and N-acylhomocysteine thiolactone (AHT) analogues is explored, greatly extending the ability to detect a wide spectrum of AHL signal molecules.

TL;DR: Quorum sensing enables a bacterial population to mount a co-operative response that improves access to nutrients or specific environmental niches, promotes collective defence against other competitor prokaryotes or eukaryotic defence mechanisms and facilitates survival through differentiation into morphological forms better able to combat environmental threats.

TL;DR: In this paper, two quorum-sensing regulons have been identified in Pseudomonas aeruginosa, in which the LuxR homologues LasR and rhlR are activated by N-(3-oxododecanoyl)-L-homoserine lactone (OdDHL) and N-butanoy l-L-Homoserine L-homone (BHL) respectively.

TL;DR: QS signal molecules, although largely considered as effectors of QS-dependent gene expression are also emerging as multifunctional molecules that influence life, development and death in single and mixed microbial populations and impact significantly the outcome of host-pathogen interactions.

TL;DR: QS contributes to environmental adaptation by facilitating the elaboration of virulence determinants in pathogenic species and plant biocontrol characteristics in beneficial species as well as directing biofilm formation and colony escape and crosses the prokaryotic-eukaryotic boundary in that QS signal molecules influence the behaviour of eukaryotes in both the plant and mammalian worlds.