P
Paula Herman
Researcher at Harvard University
Publications - 8
Citations - 11181
Paula Herman is an academic researcher from Harvard University. The author has contributed to research in topics: Enhancer & Cancer. The author has an hindex of 8, co-authored 8 publications receiving 10657 citations. Previous affiliations of Paula Herman include Brigham and Women's Hospital.
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Journal ArticleDOI
EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy.
J. Guillermo Paez,Pasi A. Jänne,Pasi A. Jänne,Jeffrey C. Lee,Sean Tracy,Heidi Greulich,Heidi Greulich,Stacey Gabriel,Paula Herman,Frederic J. Kaye,Neal I. Lindeman,Titus J. Boggon,Katsuhiko Naoki,Hidefumini Sasaki,Yoshitaka Fujii,Michael J. Eck,William R. Sellers,William R. Sellers,William R. Sellers,Bruce E. Johnson,Bruce E. Johnson,Matthew Meyerson,Matthew Meyerson +22 more
TL;DR: Results suggest that EGFR mutations may predict sensitivity to gefitinib, and treatment with the EGFR kinase inhibitor gefitsinib causes tumor regression in some patients with NSCLC, more frequently in Japan.
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The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.
Mark Pomerantz,Nasim Ahmadiyeh,Nasim Ahmadiyeh,Li Jia,Paula Herman,Michael P. Verzi,Harshavardhan Doddapaneni,Christine A. Beckwith,Jennifer A. Chan,Adam Hills,Matthew J. Davis,Keluo Yao,Sarah M. Kehoe,Heinz-Josef Lenz,Christopher A. Haiman,Chunli Yan,Brian E. Henderson,Baruch Frenkel,Jordi Barretina,Adam J. Bass,Josep Tabernero,José Baselga,Meredith M. Regan,J. Robert Manak,Ramesh A. Shivdasani,Gerhard A. Coetzee,Matthew L. Freedman,Matthew L. Freedman +27 more
TL;DR: Evidence is presented that the region harboring this variant is a transcriptional enhancer, that the alleles of rs6983267 differentially bind transcription factor 7-like 2 (TCF7L2) and that the risk region physically interacts with the MYC proto-oncogene.
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8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC
Nasim Ahmadiyeh,Mark Pomerantz,Chiara Grisanzio,Paula Herman,Li Jia,Vanessa Almendro,Housheng Hansen He,Myles Brown,X. Shirley Liu,Matthew J. Davis,Jennifer L. Caswell,Christine A. Beckwith,Adam Hills,Laura E. MacConaill,Gerhard A. Coetzee,Meredith M. Regan,Matthew L. Freedman +16 more
TL;DR: Data is presented showing that each risk locus bears epigenetic marks consistent with enhancer elements and forms a long-range chromatin loop with the MYC proto-oncogene located several hundred kilobases telomeric and that these interactions are tissue-specific.
Journal ArticleDOI
Genome coverage and sequence fidelity of ϕ29 polymerase‐based multiple strand displacement whole genome amplification
J. Guillermo Paez,Ming Lin,Rameen Beroukhim,Jeffrey C. Lee,Xiaojun Zhao,Daniel J. Richter,Stacey Gabriel,Paula Herman,Hidefumi Sasaki,David Altshuler,Cheng Li,Matthew Meyerson,William R. Sellers +12 more
TL;DR: In this article, the fidelity and genome representation of f29 polymerase-based genome amplification (f29MDA) using direct sequencing and high density oligonucleotide arrays probing >10 000 SNP alleles were tested.
Journal ArticleDOI
Functional Enhancers at the Gene-Poor 8q24 Cancer-Linked Locus
Li Jia,Gilad Landan,Mark Pomerantz,Rami Jaschek,Paula Herman,David Reich,Chunli Yan,Omar Khalid,Phil Kantoff,William Oh,J. Robert Manak,Benjamin P. Berman,Brian E. Henderson,Baruch Frenkel,Christopher A. Haiman,Matthew L. Freedman,Matthew L. Freedman,Amos Tanay,Gerhard A. Coetzee +18 more
TL;DR: The study reported here exemplifies an approach that may be applied to any risk-associated allele in non-protein coding regions as it emerges from genome-wide association studies to better understand the genetic predisposition of complex diseases.