Paula Licona-Limón

TL;DR: The hypothesis that blocking TGFβ-induced signalling in the tumour microenvironment enhances antitumour immunity and may be beneficial for cancer therapy is favoured.

TL;DR: The coexpression of CD49b and LAG-3 enables the isolation of highly suppressive human Tr 1 cells from in vitro anergized cultures and allows the tracking of Tr1 cells in the peripheral blood of subjects who developed tolerance after allogeneic hematopoietic stem cell transplantation.

TL;DR: Two new fate-mapping mouse models are used to show that CD4+ T cells that formerly expressed IL-17A go on to acquire an anti-inflammatory phenotype and suggest that Th17 cell instability and plasticity is a therapeutic opportunity for inflammatory diseases.

TL;DR: Interactions between ILC2 cells and the adaptive immune system, as well as examination of potential roles for I LC2 cells in the maintenance of homeostasis, promise to be particularly fruitful areas of future research.

TL;DR: This work has defined a specific DC subset that is involved in Th2 cell differentiation in vivo in response to a protease allergen, as well as infection with Nippostrongylus brasiliensis, and demonstrated that this subset is controlled by the transcription factor interferon regulatory factor 4 (IRF4), which is required for their differentiation and Th 2 cell-inducing function.