P
Paulina A. Hawkins
Researcher at Emory University
Publications - 37
Citations - 932
Paulina A. Hawkins is an academic researcher from Emory University. The author has contributed to research in topics: Serotype & Pneumococcal conjugate vaccine. The author has an hindex of 12, co-authored 28 publications receiving 636 citations. Previous affiliations of Paulina A. Hawkins include National Center for Immunization and Respiratory Diseases & Centers for Disease Control and Prevention.
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Journal ArticleDOI
Strain features and distributions in pneumococci from children with invasive disease before and after 13-valent conjugate vaccine implementation in the USA.
Benjamin J. Metcalf,Robert E. Gertz,Rebecca A. Gladstone,Rebecca A. Gladstone,Hollis Walker,Logan K. Sherwood,Delois Jackson,Zhongya Li,Caitlin Law,Paulina A. Hawkins,Sopio Chochua,Mili Sheth,Nabin Rayamajhi,Stephen D. Bentley,Stephen D. Bentley,Lindsay Kim,Cynthia G. Whitney,Lesley McGee,Bernard Beall +18 more
TL;DR: The results serve as a reference describing key features of current paediatric IPD strains in the USA after PCV13 implementation.
Journal ArticleDOI
Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study.
Stephanie W. Lo,Rebecca A. Gladstone,Andries J. van Tonder,John A. Lees,Mignon du Plessis,Rachel Benisty,Noga Givon-Lavi,Paulina A. Hawkins,Jennifer E. Cornick,Brenda Kwambana-Adams,Brenda Kwambana-Adams,Pierra Y. Law,Pak-Leung Ho,Martin Antonio,Dean Everett,Ron Dagan,Anne von Gottberg,Keith P. Klugman,Lesley McGee,Robert F. Breiman,Stephen D. Bentley,Abdullah Brooks,Alejandra Corso,Alexander Davydov,Alison J. Maguire,Andrew J. Pollard,Anmol M. Kiran,Anna Skoczynska,Benild Moiane,Bernard Beall,Betuel Sigaúque,David M. Aanensen,Deborah Lehmann,Diego Faccone,Ebenezer Foster-Nyarko,Ebrima Bojang,Ekaterina Egorova,Elena Voropaeva,Eric Sampane-Donkor,Ewa Sadowy,Godfrey Bigogo,Helio Mucavele,Houria Belabbès,Idrissa Diawara,Jennifer C. Moïsi,Jennifer R. Verani,Jeremy D. Keenan,Jyothish N Nair Thulasee Bhai,Kedibone M. Ndlangisa,Khalid Zerouali,K L Ravikumar,Leonid Titov,Linda de Gouveia,Maaike Alaerts,Margaret Ip,Maria Cristina de Cunto Brandileone,Hasanuzzaman,Metka Paragi,Michele Nurse-Lucas,Mushal Ali,Naima Elmdaghri,Nicholas J. Croucher,Nicole Wolter,Nurit Porat,Ozgen Koseoglu Eser,Patrick Eberechi Akpaka,Paul Turner,Paula Gagetti,Peggy-Estelle Tientcheu,Philip E. Carter,Rafal Mostowy,Rama Kandasamy,Rebecca Ford,Rebecca Henderson,Roly Malaker,Sadia Shakoor,Samanta Cristine Grassi Almeida,Samir K. Saha,Sanjay Doiphode,Shabir A. Madhi,Shamala Devi Sekaran,Somporn Srifuengfung,Stephen K. Obaro,Stuart C. Clarke,Susan A. Nzenze,Tamara Kastrin,Theresa J. Ochoa,Veeraraghavan Balaji,Waleria Hryniewicz,Yulia Urban +89 more
TL;DR: In this paper, a whole-genome sequenced 3233 invasive pneumococcal disease isolates from laboratory-based surveillance programs in Hong Kong (n=78), Israel, South Africa, Malawi, Nigeria, The Gambia, and USA were collected from children younger than 3 years.
Journal ArticleDOI
International genomic definition of pneumococcal lineages, to contextualise disease, antibiotic resistance and vaccine impact
Rebecca A. Gladstone,Stephanie W. Lo,John A. Lees,Nicholas J. Croucher,Andries J. van Tonder,Jukka Corander,Jukka Corander,Andrew J. Page,Pekka Marttinen,Leon J. Bentley,Theresa J. Ochoa,Pak-Leung Ho,Mignon du Plessis,Jennifer E. Cornick,Brenda Kwambana-Adams,Brenda Kwambana-Adams,Rachel Benisty,Susan A. Nzenze,Shabir A. Madhi,Paulina A. Hawkins,Dean Everett,Martin Antonio,Martin Antonio,Ron Dagan,Keith P. Klugman,Anne von Gottberg,Lesley McGee,Robert F. Breiman,Stephen D. Bentley +28 more
TL;DR: Existing non-vaccine-serotypes in most GPSCs preclude the removal of these lineages by pneumococcal conjugate vaccines; leaving potential for serotype replacement, and a subset of GPSCs have increased resistance, and/or serotype-independent invasiveness.
Journal ArticleDOI
Using whole genome sequencing to identify resistance determinants and predict antimicrobial resistance phenotypes for year 2015 invasive pneumococcal disease isolates recovered in the United States
Ben J. Metcalf,Sopio Chochua,Robert E. Gertz,Zhongya Li,Hollis Walker,T. Tran,Paulina A. Hawkins,Anita Glennen,Ruth Lynfield,Y. Li,Lesley McGee,Bernard Beall,Art Reingold,S. Brooks,H. Randel,Lisa Miller,B. White,Deborah Aragon,Meghan Barnes,J. Sadlowski,Sue Petit,Matthew L. Cartter,C. Marquez,M. Wilson,Monica M. Farley,Stepy Thomas,Amy Tunali,W. Baughman,Lee H. Harrison,J. Benton,T. Carter,Rosemary Hollick,K. Holmes,A. Riner,Corinne Holtzman,Richard Danila,K. MacInnes,Karen Scherzinger,Kathy Angeles,Joseph Bareta,L. Butler,S. Khanlian,R. Mansmann,Megin Nichols,Nancy M. Bennett,S. Zansky,S. Currenti,Suzanne McGuire,Ann Thomas,M. Schmidt,Jamie Thompson,Tasha Poissant,William Schaffner,Brenda Barnes,K. Leib,K. Dyer,L. McKnight,R. Gierke,Olivia Almendares,J. Hudson,L. McGlone,Gayle Fischer Langley +61 more
TL;DR: WGS-based antimicrobial phenotype prediction was an informative alternative to BDT for invasive pneumococci and correctly predicted penicillin-binding protein types and common resistance determinants.
Journal ArticleDOI
Short-read whole genome sequencing for determination of antimicrobial resistance mechanisms and capsular serotypes of current invasive Streptococcus agalactiae recovered in the USA
Benjamin J. Metcalf,Sopio Chochua,Robert E. Gertz,Paulina A. Hawkins,Jessica N. Ricaldi,Zhongya Li,Hollis Walker,T. Tran,J. Rivers,S. Mathis,Delois Jackson,Anita Glennen,Ruth Lynfield,Lesley McGee,Bernard Beall,Art Reingold,S. Brooks,H. Randel,Lisa Miller,B. White,Deborah Aragon,Meghan Barnes,J. Sadlowski,Sue Petit,Matthew L. Cartter,C. Marquez,M. Wilson,Monica M. Farley,Stepy Thomas,Amy Tunali,W. Baughman,Lee H. Harrison,J. Benton,T. Carter,Rosemary Hollick,K. Holmes,A. Riner,Corinne Holtzman,Richard Danila,K. MacInnes,Karen Scherzinger,Kathy Angeles,Joseph Bareta,L. Butler,S. Khanlian,R. Mansmann,Megin Nichols,Nancy M. Bennett,S. Zansky,S. Currenti,Suzanne McGuire,Ann Thomas,M. Schmidt,Jamie Thompson,Tasha Poissant,William Schaffner,Brenda Barnes,K. Leib,K. Dyer,L. McKnight,Olivia Almendares,J. Hudson,L. McGlone,Cynthia G. Whitney,Stephanie J. Schrag,Gayle Fischer Langley +65 more
TL;DR: The WGS-based assignment of iGBS resistance features and serotypes is an accurate substitute for phenotypic testing.