Showing papers by "Paulus Kirchhof published in 1998"
TL;DR: In this paper, the effects of propafenone and procainamide on these parameters, and their antiarrhythmic or proarrhythmmic consequences, were investigated in 11 isolated Langendorff-perfused rabbit hearts, monophasic action potentials were recorded simultaneously from six to seven different right and left ventricular sites, along with a volume-conducted ECG.
Abstract: Background—Conduction block may be both antiarrhythmic and proarrhythmic. Drug-induced postrepolarization refractoriness (PRR) may prevent premature excitation and tachyarrhythmia induction. The effects of propafenone and procainamide on these parameters, and their antiarrhythmic or proarrhythmic consequences, were investigated. Methods and Results—In 11 isolated Langendorff-perfused rabbit hearts, monophasic action potentials (MAPs) were recorded simultaneously from six to seven different right and left ventricular sites, along with a volume-conducted ECG. All recordings were used to discern ventricular tachycardia (VT) or ventricular fibrillation (VF) induced by repetitive extrastimulation (S2-S5) or 10-second burst stimulation at 25 to 200 Hz at baseline and after addition of procainamide (20 μmol/L) or propafenone (1 μmol/L) to the perfusate. MAPs were analyzed for action potential duration at 90% repolarization (APD90), conduction times (CT) between the pacing site and the other MAPs, and PRR (effect...
88 citations
TL;DR: Gradual synchronization of activation is part of the electrophysiological mechanism resulting in spontaneous ventricular fibrillation termination and can be detected three activations before termination, and phase angle convergence may be useful to detect spontaneous termination of ventricularfibrillation.
Abstract: Aims To elucidate the mechanism of spontaneous termination of ventricular fibrillation (VF) and to define an indicator of its occurrence, the phase angle, a novel measure to assess synchrony of activation, was evaluated.
12 citations