P
Paweł Wityk
Researcher at Gdańsk University of Technology
Publications - 21
Citations - 265
Paweł Wityk is an academic researcher from Gdańsk University of Technology. The author has contributed to research in topics: DNA damage & Medicine. The author has an hindex of 6, co-authored 17 publications receiving 159 citations. Previous affiliations of Paweł Wityk include University of Gdańsk.
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Journal ArticleDOI
Mechanisms of Damage to DNA Labeled with Electrophilic Nucleobases Induced by Ionizing or UV Radiation.
Janusz Rak,Lidia Chomicz,Justyna Wiczk,Kinga Westphal,Magdalena Zdrowowicz,Paweł Wityk,Michał Żyndul,Samanta Makurat,Łukasz Golon +8 more
TL;DR: It is demonstrated that the most important factors deciding on radiodamage to the labeled DNA are the electron affinity of modified nucleoside (mNZ), the local surroundings of the label that significantly influences the EA of mNZ, and the strength of the chemical bond holding together the substituent and a nucleobase.
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The Many Faces of Enterococcus spp.-Commensal, Probiotic and Opportunistic Pathogen.
TL;DR: In this paper, the authors discuss both the beneficial properties of these microorganisms and the risk factors related to their evolution towards pathogenicity, which is especially relevant in hospital environments, where enterococcal outbreaks often occur.
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A first-principles study of electron attachment to the fully hydrated bromonucleobases
TL;DR: In this article, the degradation mechanism of four brominated nucleobases (BrX), potential DNA radiosensitizers, was studied in explicit water solution, using ab initio molecular dynamics.
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5-Thiocyanato-2′-deoxyuridine as a possible radiosensitizer: electron-induced formation of uracil-C5-thiyl radical and its dimerization
Magdalena Zdrowowicz,Lidia Chomicz,Michał Żyndul,Paweł Wityk,Janusz Rak,Tyler J. Wiegand,Cameron G. Hanson,Amitava Adhikary,Michael D. Sevilla +8 more
TL;DR: SCNdU is established as a potential radiosensitizer that could cause intra- and inter-strand crossl linking as well as DNA-protein crosslinking via S-S dimer formation.
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5-Selenocyanato and 5-trifluoromethanesulfonyl derivatives of 2'-deoxyuridine: synthesis, radiation and computational chemistry as well as cytotoxicity
Samanta Makurat,Magdalena Zdrowowicz,Lidia Chomicz-Mańka,Witold Kozak,Illia E. Serdiuk,Paweł Wityk,Alicja Kawecka,Marta Sosnowska,Janusz Rak +8 more
TL;DR: In this article, the electron attachment induced formation of 5-hydroxy-2′-deoxyuridine (OHdU) from OTfdU, while 2′-dU is mainly observed experimentally.