P
Paz Prieto-Martin
Researcher at Kyoto University
Publications - 4
Citations - 3700
Paz Prieto-Martin is an academic researcher from Kyoto University. The author has contributed to research in topics: Cytotoxic T cell & FOXP3. The author has an hindex of 4, co-authored 4 publications receiving 3360 citations.
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Journal ArticleDOI
CTLA-4 Control over Foxp3+ Regulatory T Cell Function
Kajsa Wing,Yasushi Onishi,Yasushi Onishi,Paz Prieto-Martin,Tomoyuki Yamaguchi,Makoto Miyara,Zoltan Fehervari,Takashi Nomura,Shimon Sakaguchi,Shimon Sakaguchi +9 more
TL;DR: It is shown that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell–mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice.
Journal ArticleDOI
Regulatory T cells: how do they suppress immune responses?
Shimon Sakaguchi,Shimon Sakaguchi,Kajsa Wing,Kajsa Wing,Yasushi Onishi,Yasushi Onishi,Paz Prieto-Martin,Tomoyuki Yamaguchi +7 more
TL;DR: This work proposes that there may be a key suppressive mechanism that is shared by every forkhead box p3 (Foxp3)(+) Treg in vivo and in vitro in mice and humans and will help to design effective ways for controlling immune responses by targeting Treg suppressive functions.
Journal ArticleDOI
Complement drives Th17 cell differentiation and triggers autoimmune arthritis
Motomu Hashimoto,Keiji Hirota,Hiroyuki Yoshitomi,Shinji Maeda,Shin Teradaira,Shuji Akizuki,Paz Prieto-Martin,Takashi Nomura,Noriko Sakaguchi,Noriko Sakaguchi,Jörg Köhl,Jörg Köhl,Birgitta Heyman,Minoru Takahashi,Teizo Fujita,Tsuneyo Mimori,Shimon Sakaguchi,Shimon Sakaguchi +17 more
TL;DR: The data suggest that complement activation by exogenous or endogenous stimulation can initiate Th17 cell differentiation and expansion in certain autoimmune diseases and presumably in microbial infections.
Journal ArticleDOI
Construction of self-recognizing regulatory T cells from conventional T cells by controlling CTLA-4 and IL-2 expression.
Tomoyuki Yamaguchi,Ayumi Kishi,Motonao Osaki,Hiromasa Morikawa,Paz Prieto-Martin,Kajsa Wing,Kajsa Wing,Takashi Saito,Shimon Sakaguchi +8 more
TL;DR: It is shown that Tconv cells rendered IL-2 deficient and constitutively expressing transgenic cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) were potently suppressive in vitro when they were preactivated by antigenic stimulation.