P
Pedro A. F. Galante
Researcher at Ludwig Institute for Cancer Research
Publications - 117
Citations - 3070
Pedro A. F. Galante is an academic researcher from Ludwig Institute for Cancer Research. The author has contributed to research in topics: Gene & Biology. The author has an hindex of 27, co-authored 98 publications receiving 2469 citations. Previous affiliations of Pedro A. F. Galante include Harvard University & University of São Paulo.
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Journal ArticleDOI
Detection and evaluation of intron retention events in the human transcriptome
TL;DR: A large-scale analysis of intron retention in a set of 21,106 known human genes suggests that a significant fraction of the observed events are not spurious and might reflect biological significance.
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Comprehensive cancer-gene panels can be used to estimate mutational load and predict clinical benefit to PD-1 blockade in clinical practice.
Luis Felipe Campesato,Romualdo Barroso-Sousa,Leandro Jimenez,Bruna R. Correa,Jorge Sabbaga,Paulo M. Hoff,Luiz F. L. Reis,Pedro A. F. Galante,Anamaria A. Camargo +8 more
TL;DR: The data reveals that CGPs can be used to estimate mutational load and to predict clinical benefit to PD-1 blockade, with similar accuracy to that reported using WES.
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A potential role for intragenic miRNAs on their hosts' interactome
Ludwig Christian Hinske,Ludwig Christian Hinske,Pedro A. F. Galante,Winston Patrick Kuo,Lucila Ohno-Machado +4 more
TL;DR: How higher-order miRNA feedback on hosts' interactomes may at least in part explain correlation patterns observed between expression of host genes and intragenic miRNA targets in healthy and tumor tissue is described.
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Recurrent somatic mutation in DROSHA induces microRNA profile changes in Wilms tumour
Giovana Tardin Torrezan,Elisa Napolitano Ferreira,Adriana M. Nakahata,Bruna D. F. Barros,Mayara T. M. Castro,Bruna R. Correa,Ana Cristina Victorino Krepischi,Eloisa Helena Ribeiro Olivieri,Isabela Werneck da Cunha,Uri Tabori,Paul E. Grundy,Cecília Maria Lima da Costa,Beatriz de Camargo,Pedro A. F. Galante,Dirce Maria Carraro +14 more
TL;DR: The data underscore the pivotal role of the miRNA biogenesis pathway in WT tumorigenesis, particularly the major miRNA-processing gene DROSHA, which leads to a predominant downregulation of a subset of miRNAs.
Journal ArticleDOI
Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line.
Qi Zhao,Otavia L. Caballero,Samuel Levy,Brian Stevenson,Christian Iseli,Sandro J. de Souza,Pedro A. F. Galante,Dana A. Busam,Margaret Leversha,Kalyani Chadalavada,Yu-Hui Rogers,J. Craig Venter,Andrew J. G. Simpson,Robert L. Strausberg +13 more
TL;DR: This approach demonstrates that high-throughput transcriptome sequencing is an effective strategy for the characterization of genomic rearrangements in cancers.