P
Pedro Marcos Gomes Soares
Researcher at Federal University of Ceará
Publications - 94
Citations - 2704
Pedro Marcos Gomes Soares is an academic researcher from Federal University of Ceará. The author has contributed to research in topics: Myeloperoxidase & Mucositis. The author has an hindex of 28, co-authored 86 publications receiving 2104 citations. Previous affiliations of Pedro Marcos Gomes Soares include University of Porto & University of Dundee.
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Journal ArticleDOI
Potent and selective chemical probe of hypoxic signalling downstream of HIF-α hydroxylation via VHL inhibition
Julianty Frost,Carles Galdeano,Carles Galdeano,Pedro Marcos Gomes Soares,M.S. Gadd,Katarzyna M. Grzes,Lucy Ellis,Ola Epemolu,Satoko Shimamura,Marcus Bantscheff,Paola Grandi,Kevin D. Read,Doreen A. Cantrell,Sonia Rocha,Alessio Ciulli +14 more
TL;DR: It is shown that VH298 engages with high affinity and specificity with VHL as its only major cellular target, leading to selective on-target accumulation of hydroxylated HIF-α in a concentration- and time-dependent fashion in different cell lines.
Journal ArticleDOI
Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution
Pedro Marcos Gomes Soares,Jose Mauricio Mota,Antoniella S. Gomes,Ricardo Brandt de Oliveira,Ana Maria Sampaio Assreuy,Gerly Anne de Castro Brito,Armênio Aguiar dos Santos,Ronaldo A. Ribeiro,Marcellus H.L.P. Souza +8 more
TL;DR: In this article, the authors evaluated 5-fluorouracil (5-FU)-induced intestinal motility during 5-FU-induced intestinal mucositis in Wistar rats, and found a significant increase in gastric fundus and duodenum smooth muscle contraction after both the 3rd and 15th day.
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Role of the NO/cGMP/K(ATP) pathway in the protective effects of sildenafil against ethanol-induced gastric damage in rats.
Jand Venes R. Medeiros,Gemima G. Gadelha,Samara J. Lima,J A Garcia,Pedro Marcos Gomes Soares,Armênio Aguiar dos Santos,Gerly Anne de Castro Brito,Ronaldo A. Ribeiro,Marcellus H.L.P. Souza +8 more
TL;DR: The objective was to evaluate the role of the NO/cGMP/KATP pathway in the protective effects of sildenafil against ethanol‐induced gastric damage.
Journal ArticleDOI
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)
Pedro Marcos Gomes Soares,M.S. Gadd,Julianty Frost,Carles Galdeano,Lucy Ellis,Ola Epemolu,Sonia Rocha,Kevin D. Read,Alessio Ciulli +8 more
TL;DR: The structure-guided design and group-based optimization of a series of VHL inhibitors with low nanomolar potencies and improved cellular permeability are reported, leading to the discovery of potent inhibitors 10 and chemical probe VH298, with dissociation constants <100 nM, which induced marked HIF-1α intracellular stabilization.
Journal ArticleDOI
Antinociceptive properties of the essential oil of Ocimum gratissimum L. (Labiatae) in mice
M. Rabelo,Emmanuel P. Souza,Pedro Marcos Gomes Soares,A.V. Miranda,Francisco José de Abreu Matos,David N. Criddle,David N. Criddle +6 more
TL;DR: EOOG possesses interesting antinociceptive properties in the writhing and formalin tests, and due to the relatively low toxicity of EOOG, further detailed examination is strongly indicated for a better characterization of its pharmacological properties and its potential therapeutic value.