Peipei Jiang

TL;DR: In this study, the sustained-release system of bFGF 100 µg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients and showed that after treatment, the menstrual blood volume, endometrial thickness and the scarredendometrial area were improved.

TL;DR: The results uncovered aberrant SEMA3, EGF, PTN, and TWEAK signaling pathways as causes for the insufficient proliferation of the endometrium and provide insight into therapeutic strategies for endometrial regeneration and growth to treat thin endometria.

TL;DR: It is demonstrated that the DUSP4/GSK-3β/SNAI1 pathway was critical in transducing the pro-EMT signals initiated by ΔNp63α, while bFGF reversed ΔN p63α-induced EMT and endometrial fibrosis both in vitro and in vivo.

TL;DR: In this article, the authors provided evidence that upregulation of circPTPN12 in endometrial epithelial cells (EECs) of fibrotic endometrium functions as endogenous sponge of miR21-5 p to inhibit miR-21- 5 p expression and activity, which in turn results in upregulated of ΔNp63α to induce the epithelial mesenchymal transition (EMT) of EECs (eEC-EMT).

TL;DR: This paper performed single-cell RNA sequencing of human spinal cord cells during embryonic and fetal stages that cover neuron generation as well as astrocytes and oligodendrocyte differentiation.