P
Pek Lim Chu
Researcher at National University of Singapore
Publications - 7
Citations - 110
Pek Lim Chu is an academic researcher from National University of Singapore. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 2, co-authored 4 publications receiving 46 citations.
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Journal ArticleDOI
Upconversion superballs for programmable photoactivation of therapeutics.
Zhen Zhang,Muthu Kumara Gnanasammandhan Jayakumar,Xiang Zheng,Swati Shikha,Yi Zhang,Akshaya Bansal,Dennis J.J. Poon,Pek Lim Chu,Eugenia Li Ling Yeo,Melvin L.K. Chua,Soo Khee Chee,Yong Zhang +11 more
TL;DR: The authors report on an assembly process of two distinct nanoparticles into composite nanoparticles as a simple method and report on the application in photodynamic therapy and siRNA delivery in tumour therapy.
Journal ArticleDOI
Vandetanib sensitizes head and neck squamous cell carcinoma to photodynamic therapy through modulation of EGFR-dependent DNA repair and the tumour microenvironment.
Pek Lim Chu,Waseem Ahamed Shihabuddeen,Kar Perng Low,Dennis J.J. Poon,Bhuvaneswari Ramaswamy,Zhong-Guo Liang,Wen Long Nei,Kevin L.M. Chua,Patricia S. P. Thong,Khee Chee Soo,Eugenia Li Ling Yeo,Melvin L.K. Chua +11 more
TL;DR: Vandetanib enhances the efficacy of PDT through both direct and indirect effects on the cellular DNA repair machinery and tumour microenvironment, respectively, corroborating the importance of microenvironmental modification for the observed drug-PDT synergistic interaction.
Journal ArticleDOI
High-Dimensional Characterization of the Systemic Immune Landscape Informs on Synergism Between Radiation Therapy and Immune Checkpoint Blockade.
Kevin L.M. Chua,Michael G. Fehlings,Eugenia Li Ling Yeo,Alessandra Nardin,Hermi Sumatoh,Pek Lim Chu,Wen-long Nei,Enya H.W. Ong,Wai Yee Woo,Kar Perng Low,Haitao Wang,Dennis J.J. Poon,Zhong-Guo Liang,Kai Yao,Luo Huang,Chee Keong Toh,Mei-Kim Ang,Mohamad Farid,Xin Min Cheng,Ravindran Kanesvaran,Rebecca Dent,Joseph Wee,Tony Kiat Hon Lim,N. Gopalakrishna Iyer,Daniel Shao-Weng Tan,Khee Chee Soo,Evan W. Newell,Evan W. Newell,Melvin L.K. Chua +28 more
TL;DR: Findings point towards a sustained reinvigoration of host anti-tumor immunity following RT-ICB, and suggest an expansion in activated Ki-67+ CD8+ T cells as a possible demonstration of this synergy, thereby providing new insights which may support the development of optimal sequencing strategies.
Journal ArticleDOI
Repurposing Proton Beam Therapy through Novel Insights into Tumour Radioresistance.
TL;DR: In this paper, the role of proton beam therapy (PBT) in addressing radioresistance, through better patient selection, and by providing an improved toxicity profile for integration with novel agents.
Journal ArticleDOI
Genome-wide identification and expression analysis of SlRR genes in response to abiotic stresses in tomato.
He Liu,R. Chen,H S. Li,J Lin,Yu Wang,M. Han,Ti Wang,H. M. Wang,Q. Chen,F. Chen,Pek Lim Chu,C. Liang,Chunyuan Ren,Y. Zhang,F. Yang,Yunyan Sheng,J Wei,Weikang Xia,G B Yu +18 more
TL;DR: In this article , the diversity and function of response regulator (RR) genes, a critical component of TCS, in tomato was characterized by qRT-PCR and was complemented by the available transcriptional data under these treatments.