P
Peng Zhang
Researcher at Beijing University of Posts and Telecommunications
Publications - 71
Citations - 4276
Peng Zhang is an academic researcher from Beijing University of Posts and Telecommunications. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 20, co-authored 61 publications receiving 3715 citations. Previous affiliations of Peng Zhang include Xuzhou Medical College & Sichuan University.
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Journal ArticleDOI
Use of Arsenic Trioxide (As2O3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients
Zhi-Xiang Shen,Guo-Qiang Chen,Jian-Hua Ni,Xiu-Shong Li,Shu-Min Xiong,Qian-Yao Qiu,Jun Zhu,Wei Tang,Guan-Lin Sun,Kan-Qi Yang,Yu Chen,Li Zhou,Zhi-Wen Fang,Yan-Ting Wang,Jun Ma,Peng Zhang,Ting-Dong Zhang,Sai-Juan Chen,Zhu Chen,Zhen-Yi Wang +19 more
TL;DR: As2O3 treatment is an effective and relatively safe drug in APL patients refractory to ATRA and conventional chemotherapy, and Pharmacokinetic studies showed that after a peak level of 5.54 micromol/L, plasma arsenic was rapidly eliminated, and the continuous administration of As2O2 did not alter its pharmacokinetic behaviors.
Journal ArticleDOI
In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
Guo-Qiang Chen,Jun Zhu,Xue-Geng Shi,Jian-Hua Ni,Hao-Jie Zhong,Gui-Ying Si,Xiao-Long Jin,Wei Tang,Xiu-Shong Li,Shu-Ming Xong,Zhi-Xiang Shen,Guan-Lin Sun,Jun Ma,Peng Zhang,Ting-Dong Zhang,Claude Gazin,Tomoki Naoe,Sai-Juan Chen,Zhen-Yi Wang,Zhu Chen +19 more
TL;DR: In this paper, As2O3 was shown to trigger NB4 cell apoptosis at micromolar concentration, as proved by morphology, histogramic related nuclear DNA contents, and DNA gel eletrophoresis.
Journal ArticleDOI
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells
Guo-Qiang Chen,Xue-Geng Shi,Wei Tang,Shu-Min Xiong,Jun Zhu,Xun Cai,Ze-Guang Han,Jian-Hua Ni,Gui-Ying Shi,Pei-Ming Jia,Meng-Min Liu,Kai-Li He,Chao Niu,Jun Ma,Peng Zhang,Ting-Dong Zhang,Pascale Paul,Tomoki Naoe,Kunio Kitamura,Wilson H. Miller,Samuel Waxman,Zhen-Yi Wang,Sai-Juan Chen,Zhu Chen +23 more
TL;DR: Combination of induction of apoptosis and partial differention could be the main cellular mechanisms of As2O3 in the treatment of APL, and PML-RAR alpha could play an important role in determining the specific effects of As 2O3 on APL cells.
Journal ArticleDOI
β-glucan attenuates cognitive impairment via the gut-brain axis in diet-induced obese mice.
Hongli Shi,Yinghua Yu,Danhong Lin,Peng Zheng,Peng Zheng,Peng Zhang,Minmin Hu,Qiao Wang,Wei Pan,Xiaoying Yang,Tao Hu,Qianqian Li,Renxian Tang,Feng Zhou,Kuiyang Zheng,Xu-Feng Huang,Xu-Feng Huang +16 more
TL;DR: The data suggest that elevating consumption of β-glucan-rich foods is an easily implementable nutritional strategy to alleviate detrimental features of gut-brain dysregulation and prevent neurodegenerative diseases associated with Westernized dietary patterns.
Journal ArticleDOI
Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis.
Bing Chen,Zijing Xia,Ya-nan Deng,Yanfang Yang,Peng Zhang,Hongxia Zhu,Ningzhi Xu,Ningzhi Xu,Shufang Liang +8 more
TL;DR: The progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA biomarkers for CRC diagnosis, treatment and recurrence prediction are summarized.