P
Penghui Xu
Researcher at Nanjing Medical University
Publications - 9
Citations - 805
Penghui Xu is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: microRNA & Circular RNA. The author has an hindex of 6, co-authored 9 publications receiving 435 citations.
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Journal ArticleDOI
Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway
Xing Zhang,Sen Wang,Haixiao Wang,Jiacheng Cao,Xiaoxu Huang,Zheng Chen,Penghui Xu,Guangli Sun,Jianghao Xu,Jialun Lv,Zekuan Xu +10 more
TL;DR: It is proved that circNRIP1 sponges miR-149-5p to affect the expression level of AKT1 and eventually acts as a tumour promotor in GC and demonstrated that quaking can promote circ NRIP1 transcription.
Journal ArticleDOI
Novel role of miR-133a-3p in repressing gastric cancer growth and metastasis via blocking autophagy-mediated glutaminolysis
Xing Zhang,Zheng Li,Zhe Xuan,Penghui Xu,Weizhi Wang,Zheng Chen,Sen Wang,Guangli Sun,Jianghao Xu,Zekuan Xu +9 more
TL;DR: It is demonstrated that microRNA-133a-3p overexpression could block the activation of autophagy to ruin the abnormal glutaminolysis and further inhibit the growth and metastasis of gastric cancer cells.
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Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer
Sen Wang,Xing Zhang,Zheng Li,Weizhi Wang,Bowen Li,Xiaoxu Huang,Guangli Sun,Jianghao Xu,Qing Li,Zhipeng Xu,Yiwen Xia,Lu Wang,Qiang Zhang,Qiang Li,Lu Zhang,Jie Chen,Yangjun Wu,Jiacheng Cao,Penghui Xu,Diancai Zhang,Hao Xu,Zekuan Xu +21 more
TL;DR: The findings reveal that circOSBPL10 may serve as a new proliferation factor and prognostic marker in GC and that miR-136-5p is a downstream target of circOSbPL10 using RNA pull-down and luciferase reporter assays.
Journal ArticleDOI
Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression.
Guangli Sun,Zheng Li,Zhongyuan He,Weizhi Wang,Sen Wang,Xing Zhang,Jiacheng Cao,Penghui Xu,Haixiao Wang,Xiaoxu Huang,Yiwen Xia,Jialun Lv,Zhe Xuan,Tianlu Jiang,Lang Fang,Jing Yang,Diancai Zhang,Hao Xu,Zekuan Xu +18 more
TL;DR: Overexpression of CircMCTP2 could be a new therapeutic strategy for counteracting CDDP resistance in GC and sensitizes GC to CDDP through the upregulation of MTMR3 by sponging miR-99a-5p.
Journal ArticleDOI
Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway.
Jiacheng Cao,Xing Zhang,Penghui Xu,Haixiao Wang,Sen Wang,Lu Zhang,Zheng Li,Li Xie,Guangli Sun,Yiwen Xia,Jialun Lv,Jing Yang,Zekuan Xu +12 more
TL;DR: In this article, the authors showed that circLMO7-miR-30a-3p-WNT2 axis could promote the growth and metastasis of GC in vivo by the establishment of nude mouse models.