P
Pengyuan Yang
Researcher at Chinese Academy of Sciences
Publications - 61
Citations - 2934
Pengyuan Yang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Hepatocellular carcinoma & Tumor microenvironment. The author has an hindex of 23, co-authored 57 publications receiving 2249 citations. Previous affiliations of Pengyuan Yang include University of Science and Technology of China & Duke University.
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Journal ArticleDOI
TGF-β-miR-34a-CCL22 Signaling-Induced Treg Cell Recruitment Promotes Venous Metastases of HBV-Positive Hepatocellular Carcinoma
Pengyuan Yang,Qi-Jing Li,Yuxiong Feng,Yun Zhang,Geoffrey J. Markowitz,Shanglei Ning,Yue-Zhen Deng,Jiang-Sha Zhao,Shan Jiang,Yunfei Yuan,Hongyang Wang,Shu-Qun Cheng,Dong Xie,Xiao-Fan Wang +13 more
TL;DR: It is suggested that HBV infection and activity of the TGF-β-miR-34a-CCL22 axis serve as potent etiological factors to predispose HCC patients for the development of PVTT, possibly through the creation of an immune-subversive microenvironment to favor colonization of disseminated HCC cells in the portal venous system.
Journal ArticleDOI
The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.
TL;DR: The cytosolic nucleic acid–binding protein LRRFIP1 contributed to the production of interferon-β (IFN-β) induced by vesicular stomatitis virus (VSV) and Listeria monocytogenes in macrophages.
Journal ArticleDOI
miR-126 and miR-126* repress recruitment of mesenchymal stem cells and inflammatory monocytes to inhibit breast cancer metastasis
Yun Zhang,Pengyuan Yang,Pengyuan Yang,Tao Sun,Dong Li,Xin Xu,Yaocheng Rui,Chaoran Li,Mengyang Chong,Toni Ibrahim,Laura Mercatali,Dino Amadori,Xincheng Lu,Dong Xie,Qi-Jing Li,Xiao-Fan Wang +15 more
TL;DR: Findings determine how this microRNA pair alters the composition of the primary tumour microenvironment to favour breast cancer metastasis, and demonstrate a correlation between miR-126/126* downregulation and poor metastasis-free survival of breast cancer patients.
Journal ArticleDOI
RNA m6A methylation orchestrates cancer growth and metastasis via macrophage reprogramming.
Huilong Yin,Xiang Zhang,Pengyuan Yang,Xiaofang Zhang,Yingran Peng,Da Li,Yanping Yu,Ye Wu,Yidi Wang,Jinbao Zhang,Xiaochen Ding,Xiangpeng Wang,Angang Yang,Angang Yang,Rui Zhang +14 more
TL;DR: In this paper, the role of m6A modification in macrophages is investigated and it is shown that ablation of Mettl3 in myeloid cells promotes tumour growth and metastasis in vivo.
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MicroRNA-125a/b-5p inhibits endothelin-1 expression in vascular endothelial cells.
Dong Li,Pengyuan Yang,Qinghui Xiong,Xuhui Song,Xiangqun Yang,Lin Liu,Wenjun Yuan,Yao-Cheng Rui +7 more
TL;DR: It is demonstrated that endothelial miR-125a/b-5p inhibits ET-1 expression in VECs, which revealed a novel miRNA-mediated mechanism in vasomotor homeostasis.