Peter A. Smith

TL;DR: It is suggested that drugs that affect multiple processes, rather than a single specific target, show the greatest promise for future therapeutic development.

TL;DR: The data suggest that axotomy-induced increases in excitability are associated with decreases in I(K) and/or decreases in g(K,Ca) that are secondary to decreased Ca2+ influx, and supports the hypothesis that autotomy, that may be related to human neuropathic pain, is associated with changes in the properties of large myelinated sensory neurons.

TL;DR: The onset of autotomy coincided with alterations in the excitability of large, putative nonnociceptive, neurons, whereas small cells from the autotomy group were only slightly more excitable, consistent with the hypothesis that the onset of Autotomy is associated with changes in the properties of myelinated fibers.

TL;DR: To isolate and investigate cellular mechanisms underlying "centralization", sciatic nerves of 20-day-old rats were subjected to chronic constriction injury and CCI increased the amplitude and frequency of spontaneous and miniature excitatory postsynaptic currents (EPSCs) in delay, transient, and irregular cells.

TL;DR: It is suggested that CCI enhances excitatory synaptic drive to excite neurons but decreases that to inhibitory neurons, and both effects are mediated by nerve injury‐induced release of BDNF from microglia.