P
Peter B. Rosenthal
Researcher at Laboratory of Molecular Biology
Publications - 3
Citations - 2097
Peter B. Rosenthal is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Neuraminidase & Citric acid cycle. The author has an hindex of 3, co-authored 3 publications receiving 1702 citations.
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Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy.
TL;DR: The hand determination and refinement optimization procedure is applied to image pairs of the dihydrolipoyl acetyltransferase (E2) catalytic core of the pyruvate dehydrogenase complex from Bacillus stearothermophilus taken by low-dose electron cryomicroscopy.
Journal ArticleDOI
Molecular architecture and mechanism of an icosahedral pyruvate dehydrogenase complex: a multifunctional catalytic machine
Jacqueline L. S. Milne,Dan Shi,Peter B. Rosenthal,Joshua Sunshine,Gonzalo J. Domingo,Xiongwu Wu,Bernard R. Brooks,Richard N. Perham,Richard Henderson,Sriram Subramaniam +9 more
TL;DR: A 3D model for an 11 MDa, icosahedral pyruvate dehydrogenase sub‐complex is reported, obtained by combining a 28 Å structure derived from electron cryo‐microscopy with previously determined atomic coordinates of the individual E1 and E2 components.
Journal ArticleDOI
Structure of an Influenza Neuraminidase-Diabody Complex by Electron Cryomicroscopy and Image Analysis
TL;DR: The structure of a complex between a bivalent diabody and its antigen, influenza neuraminidase, has been determined by electron cryomicroscopy of single particles and image analysis using high-resolution X-ray models of the component proteins.