Showing papers by "Peter C Gøtzsche published in 1992"
TL;DR: It is concluded that the benefit of second-line drugs is uncertain and no evidence of a worthwhile effect on radiological changes was found.
27 citations
TL;DR: An assay based on production of HIV antigen in cultures of CD4+ lymphocytes infected 'in vitro' with cell-free virus was established and it was possible to isolate, propagate and reliably determine the zidovudine susceptibility of HIV isolates from all patients despite differences in cellular tropism and syncytium inducing capacity.
11 citations
TL;DR: The survival of 35 patients with AIDS or advanced HIV infection on treatment with zidovudine was related to the viral sensitivity to the drug and to the CD4+ cell count and large studies of combination or alternation therapy with several anti-HIV drugs should be given high priority.
Abstract: The survival of 35 patients with AIDS or advanced HIV infection on treatment with zidovu-dine was related to the viral sensitivity to the drug and to the CD4+ cell count. 14 patients died, the survivors were followed up for an average of 804 days. In a univariate Cox model, survival was strongly related to Iog IC90 (p = 0.0003) and to the CD4+ count (p = 0.0002). In a bivariate model, Iog IC90 and the CD4+ count contributed to the prediction of survival (p = 0.12 and 0.06, respectively). Large studies of combination or alternation therapy with several anti-HIV drugs should be given high priority.
4 citations