Peter D. Bittner-Eddy

TL;DR: Sequence analysis of the RRS1 genes present in two homozygous intragenic recombinant lines indicates that several domains of R RS1-R are essential for its resistance function, suggesting the existence of similar signaling pathways to those controlled by resistance genes in specific resistance.

TL;DR: Evidence of diversifying selection visible in both components suggests that the host and pathogen may be locked in a coevolutionary conflict at these loci, where attempts to evade host resistance by the pathogen are matched by the development of new detection capabilities by the host.

TL;DR: The genome sequence of the oomycete Hyaloperonospora arabidopsidis is reported, an obligate biotroph and natural pathogen of Arabidopsis thaliana, which exhibits dramatic reductions in genes encoding RXLR effectors, proteins associated with zoospore formation and motility, and enzymes for assimilation of inorganic nitrogen and sulfur.

TL;DR: Evidence is presented suggesting that the RPP genes at this locus are subject to the same selective forces that have been demonstrated for structurally different LRR-type R genes.

TL;DR: Results indicate that single alleles of the resistance gene have not swept through the population, but instead, a diverse collection of alleles have been maintained, suggesting that the extreme amino acid polymorphism in RPP13 is maintained through continual reciprocal selection between host and pathogen.