Peter Deraska

TL;DR: Outlier levels of circulatingmiR-29a-3p and miR-150-5p may eventually help predict unexpected responses to radiation therapy, such as toxicity, one may hypothesize.

TL;DR: These data support the use of MCL1 expression as a predictive biomarker for USP9X inhibitors in NSCLC therapy and help identify and characterize gene targets whose inhibition may improve RT.

TL;DR: It is demonstrated that CRISPR-mediated knockout of the little-known gene FAM122A/PABIR1 confers cellular resistance to CHK1 inhibitors (CHK1is) and cross-resistance to ATR inhibitors and can serve as a useful biomarker for predicting CHK 1i sensitivity or resistance.

TL;DR: A retrospective chart review of a convenience sample of 200 pediatric surgical patients' pain experiences during the first 24 hours after laparoscopic appendectomy demonstrates the benefits of a multimodal analgesic approach.

TL;DR: In this article, the authors performed genome-wide CRISPR-Cas9 screens in non-small-cell lung cancer (NSCLC) cell lines treated with the CHK1 inhibitor prexasertib (CHK1i).