P
Peter Dynoodt
Researcher at University College Dublin
Publications - 16
Citations - 590
Peter Dynoodt is an academic researcher from University College Dublin. The author has contributed to research in topics: Breast cancer & Melanoma. The author has an hindex of 7, co-authored 15 publications receiving 505 citations. Previous affiliations of Peter Dynoodt include Katholieke Universiteit Leuven & Ghent University Hospital.
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Journal ArticleDOI
Griscelli syndrome: a model system to study vesicular trafficking.
TL;DR: It is demonstrated that the identification and biological analysis of novel disease‐causing mutations highlighted the functional importance of the RAB27A‐MLPH‐MYO5A tripartite complex in intracellular melanosome transport.
Journal ArticleDOI
Identification of miR-145 as a key regulator of the pigmentary process
Peter Dynoodt,Pieter Mestdagh,Gert Van Peer,Jo Vandesompele,Karen Goossens,Luc Peelman,Barbara Geusens,Reinhart Speeckaert,Jo Lambert,Mireille Van Gele +9 more
TL;DR: An miRNA signature associated with forskolin and ssUV treatment is established and the significant down- or upregulation of major pigmentation genes, after modulating miR-145 expression, suggests a key role for mi R-145 in regulating melanogenesis.
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Lipid-mediated gene delivery to the skin
Barbara Geusens,Tine Strobbe,Stefanie Bracke,Peter Dynoodt,Niek N. Sanders,Mireille Van Gele,Jo Lambert +6 more
TL;DR: An overview of the different lipid vesicles that have been described in literature is given and this combined approach for some specific skin disorders is described.
Journal ArticleDOI
miR-145 overexpression suppresses the migration and invasion of metastatic melanoma cells.
Peter Dynoodt,Reinhart Speeckaert,Olivier De Wever,Ines Chevolet,Lieve Brochez,Jo Lambert,Mireille Van Gele +6 more
TL;DR: Evidence is provided that miR-145 is an invasion suppressor in metastatic melanoma cells and may serve as a useful therapeutic agent in melanoma when re-expressed in situ, despite the fact that it remains unclear which genes or pathways are regulated by miRNAs in melanomas.
Journal ArticleDOI
Comprehensive DNA methylation study identifies novel progression-related and prognostic markers for cutaneous melanoma
Jasper Wouters,Miguel Vizoso,Anna Martínez-Cardús,F. Javier Carmona,Olivier Govaere,Teresa Laguna,Jesuchristopher Joseph,Peter Dynoodt,Claudia Aura,Mona Foth,Roy Cloots,Karin van den Hurk,Balázs Bálint,Ian G. Murphy,Enda W. McDermott,Kieran Sheahan,Karin Jirström,Björn Nodin,Girish Mallya-Udupi,Joost van den Oord,William M. Gallagher,Manel Esteller,Manel Esteller +22 more
TL;DR: A prognostic signature with potential clinical applicability is determined and PON3 DNA methylation and OVOL1 protein expression are validated as biomarkers with prognostic information independent of tumor thickness and ulceration.