Peter Frey

TL;DR: These mice resemble major features of AD pathology and suggest a central role of A beta in the pathogenesis of the disease.

TL;DR: The phenotype of the exogenously induced amyloidosis depended on both the host and the source of the agent, suggesting the existence of polymorphic Aβ strains with varying biological activities reminiscent of prion strains.

TL;DR: The present results indicate that a CGRP-like peptide is present in a wide range of primary sensory neurons probably not related to specific sensory modalities and often this peptide coexists with other biologically active peptides.

TL;DR: The synthesis and characterization of the near-infrared fluorescence oxazine dye AOI987 is described, which readily penetrate the intact blood-brain barrier and binds to amyloid plaques and is an attractive probe to noninvasively monitor disease progression in animal models of Alzheimer disease and to evaluate effects of potential Alzheimer disease drugs on the plaque load.

TL;DR: While residues 20-29 contribute to the fibrils' beta-sheet core, the flanking C- and N-terminal regions of the hA peptide determine the interactions involved in the formation of higher order coiled polymorphic superstructures.