P
Peter G. Gillespie
Researcher at Oregon Health & Science University
Publications - 86
Citations - 7959
Peter G. Gillespie is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Hair cell & Myosin. The author has an hindex of 46, co-authored 86 publications receiving 7572 citations. Previous affiliations of Peter G. Gillespie include Johns Hopkins University School of Medicine & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Molecular basis of mechanosensory transduction
TL;DR: Progress in both invertebrates and vertebrates is beginning to reveal the identities of proteins essential for transduction, and the scarcity of these cells and the uniqueness of their transduction mechanisms have conspired to slow molecular characterization of the ensembles that carry out mechanotransduction.
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Unconventional Myosins in Inner-Ear Sensory Epithelia
Tama Hasson,Peter G. Gillespie,Jesus A. Garcia,Richard B. MacDonald,Yi Dong Zhao,Ann G. Yee,Mark S. Mooseker,David P. Corey +7 more
TL;DR: This work examined the distribution of four unconventional myosin isozymes in the inner ear, a tissue that is particularly reliant on actin-rich structures and unconventionalMyosin wasozymes, and localization results suggest specific functions for three hair-cell myosins.
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Cadherin 23 is a component of the tip link in hair-cell stereocilia.
Jan Siemens,Concepción Lillo,Rachel A. Dumont,Anna Reynolds,David S. Williams,Peter G. Gillespie,Ulrich Müller +6 more
TL;DR: It is shown that antibodies against CDH23 label the tip link, and that cadherin 23 has biochemical properties similar to those of theTip link, suggesting thatCDH23 and myosin-1c cooperate to regulate the activity of mechanically gated ion channels in hair cells.
Journal ArticleDOI
Mechanotransduction by Hair Cells: Models, Molecules, and Mechanisms
Peter G. Gillespie,Ulrich Müller +1 more
TL;DR: The recent discovery of several molecular constituents of the mechanotransduction machinery of hair cells provides a new framework for the interpretation of biophysical data and necessitates revision of prevailing models of mechanotranduction.
Journal ArticleDOI
A Chemical-Genetic Strategy Implicates Myosin-1c in Adaptation by Hair Cells
Jeffrey R. Holt,Susan K.H. Gillespie,D. William Provance,Kavita Shah,Kevan M. Shokat,David P. Corey,John A. Mercer,Peter G. Gillespie +7 more
TL;DR: The speed and specificity of inhibition suggests that myosin-1c participates in adaptation in hair cells, the sensory cells of the inner ear.